Allopregnanolone and 5HT1A desensitization link

This is for hypothesis and even educated speculation.
cdraham
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Allopregnanolone and 5HT1A desensitization link

Unread post by cdraham »

In conclusion, the present experiments show thatboth 3a,5a-THP and ganaxolone increase the firingactivity of 5-HT neurons, and that they both can pre-vent the citalopram-induced reduction of this activity.This not only offers a biological basis for the anti-depressant-like effect of 3a,5a-THP but also supportsthe hypothesis that ganaxolone might have such ben-eficial properties. Furthermore, our data suggest that3a,5a-THP or ganaxolone could constitute good can-didates as adjuvants to reduce the delay before thera-peutic onset, seen with SSRIs. Since naturallyoccurring neuroactive steroids might not be suitablefor chronic treatments (due to their very short half-life and side-effects profile) (Gasior et al., 2000),if ganaxolone had antidepressant properties, it couldbe especially promising as a treatment or as anadjuvant in the treatment of mood disorders in femaledepressed patients.

https://www.google.com/url?sa=t&rct=j&q ... --Ceph1VT3

https://en.wikipedia.org/wiki/Allopregnanolone

In PSSD, there could be chronically elevated high allopregnanolone levels: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23979/

Could that mean GABAa or GABAa from neurosteroids could specifically boost serotonin neuron firing to make SSRIs downregulate 5HT1A more quickly?
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