The best theory regarding PSSD.

This is for hypothesis and even educated speculation.
arahant
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Re: The best theory regarding PSSD.

Unread post by arahant »

That's the theory, and it's correct that antidepressants desensitize everything, but SSRI knocks down by serotonin overflow. That's not what buspirone does, even if it theoretically desensitize via agonism, it also reduces circulating serotonin, antidepressants do the opposite, and buspirone produces neurogenesis.
Pro sexual effects are proven in both humans and rats for decades. I have taken it for more than a year daily. It only got better over time; it looks like the theoretical desensitization is not even close to SSRIs ones (which you called antidepressants trying to put buspirone at the same category).
They have measured sexual activity, frequency, etc. These are observable results, but you are free to ignore its empirical findings in controlled trials to believe any fancy theories and/or mechanisms.
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
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