FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine

This is for hypothesis and even educated speculation.
cdraham
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FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine

Unread post by cdraham »

https://stke.sciencemag.org/content/8/404/ra119.long

"In mouse embryonic fibroblasts and primary mouse astrocytes, FKBP51 mediated several effects of paroxetine, namely, decreased the protein-protein interactions of DNMT1 with CDK5 and FKBP52, reduced phosphorylation of DNMT1, and decreased the methylation and increased the expression of the gene encoding brain-derived neurotrophic factor (Bdnf)."

Could this mean that FKBP51 is important for us? There exist drugs that target this protein.

Decreasing DMNT1 could lead to global demethylation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378172/
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