I've tried Alcar twice. Both times brain fog became significantly worse to the point I couldn't formulate sentences when talking. Not really sure if Alcar is a 5ht1a agonist, but in my experience, inhibited serotonin release in the raphe worsens brain fog. For example, I've tried alpha 1 blockers, which made brain fog and sexual symptoms much worse. Our androgenic receptors are most likely down regulated to decrease excess 5ht release induced by 5ht1a desensitization. The body is responding the right way but there is some altered regulatory mechanism keeping 5ht1a receptors desensitized.ErgogenicHealth wrote: ↑Wed Feb 03, 2021 2:05 am
Exact same here... Any 1A agonist can worsen us. That means ALCAR would crash you too?
Postsynaptic 5HT1A desensitization and my "triad of evil" hypothesis
Re: Postsynaptic 5HT1A desensitization and my "triad of evil" hypothesis
Re: Postsynaptic 5HT1A desensitization and my "triad of evil" hypothesis
What if gr receptors are too burnt out to be controlled by life stressors? Stress has no effect on me anymoreMeso wrote: ↑Mon Apr 22, 2019 1:46 pmI've considered Prednisolone, but you know that corticosteroids can induce depression by their own right if we downregulate GR too much. It's too risky. I think we better just let life stresses handle our GR regulation, imo.DrugsAreBad wrote:@Mesolimbo: How about dexamethasone?SSRIs cause HPA axis blunting through upregulating the glucocorticoid receptors, and this causes negative feedback inhibition of cortisol and the adrenals. To reverse this, we need to downregulate those receptors again.
https://academic.oup.com/mend/article-p ... nd1256.pdf
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Re: Postsynaptic 5HT1A desensitization and my "triad of evil" hypothesis
Tree wrote: ↑Wed Feb 03, 2021 9:02 pmI've tried Alcar twice. Both times brain fog became significantly worse to the point I couldn't formulate sentences when talking. Not really sure if Alcar is a 5ht1a agonist, but in my experience, inhibited serotonin release in the raphe worsens brain fog. For example, I've tried alpha 1 blockers, which made brain fog and sexual symptoms much worse. Our androgenic receptors are most likely down regulated to decrease excess 5ht release induced by 5ht1a desensitization. The body is responding the right way but there is some altered regulatory mechanism keeping 5ht1a receptors desensitized.ErgogenicHealth wrote: ↑Wed Feb 03, 2021 2:05 am
Exact same here... Any 1A agonist can worsen us. That means ALCAR would crash you too?
Super interesting, and frustrating at the same time man.
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