Just a quick suggestion: 'time-dependent sensitization'. Reportedly proposed in the 80s Louis A. Chiodo i Seymor M. Antelman. Don't ask me for more details. It's just and idea I heard somewhere (neurobiologist Jerzy Vetulani). Just some food for your thought.
"Time-dependent sensitization (TDS) has been described in animal models over the past 20 years. It is a phenomenon that occurs in a variety of biological systems, and corresponds to the cellular and systems response to a foreign or stressful stimulus. The exposure to the stimulus triggers the responses typical of that particular biological system, which are
progressively amplified with time. This phenomenon has potential major implications for clinical pharmacology. Some human studies have investigated this phenomenon to date."
https://www.researchgate.net/publicatio ... armacology
1. A number of animal studies have shown that the
actions of numerous drugs can grow or sensitize with the passage of time following even a single treatment, to achieve results equal to or greater than those seen after chronic administration. 2. Our laboratory earlier proposed that this principle might be applied to the treatment of human disorders. It was suggested that the same results might be achieved by giving drugs once every one or two weeks rather than daily, or, even more likely, several-times-daily. 3. Here the authors review the clinical literature relevant to that hypothesis, as it relates to antidepressant therapies. 4. The evidence uniformly supports our earlier thesis that the therapeutic influence of antidepressants would grow with the passage of time, even as their pharmacokinetic actions are declining.
https://www.researchgate.net/publicatio ... nt_therapy
down.
