Re: Neurotrophic Trial: 7,8-Dihydroxyflavone + Polygala Tenuifolia + Cerebrolysin + Melatonin + Noopept (PRN)
Posted: Tue Sep 07, 2021 10:58 am
[Day 26 Update]
This regimen is very nootropic already I don't feel the need to take any Noopept. I don't have brain fog anymore or any cognitive issues to speak of. Furthermore, my cognition is boosted beyond what's average to me. My mental fatigue is also reduced a little bit after dosing Cerebrolysin, but physically I still feel quite fatigued.
Polygala Tenuifolia + Cerebrolysin + Melatonin are doing all the heavy lifting. The only useless drug out of the list is actually 7,8-dihydoxyflavone. I think its bioavailability is too low even when taken sublingually. On the other hand, I feel Cerebrolysin quite strongly as it kicks in and it definitely works especially on 5 ml daily. That said, my started noticing tolerance to Cerebrolysin which means my dose of Polygala Tenuifolia wasn't enough to keep TrkB upregulated. I have since increased my Polygala Tenuifolia dose to 400 mg.
The libido improvements still persist despite the serotonergic effects of Polygala Tenuifolia.
The regimen has been changing my personality and behavior in subtle ways. Although it doesn't work for typical anhedonia and blunted affect (so far), it's bringing back the pre-PSSD procrastination, social anxiety and social anhedonia which means it's reducing cortical top-down control over the limbic system. The only drug that made me feel that way before was a D2/D3 dopamine agonist - which means this regimen is increasing limbic dopamine by a lot - although tonic release, not phasic, otherwise I'd have felt mood improvement and increased hedonic tone from it.
Although this regimen hasn't increased my hedonic tone (yet), I feel drastic mood stabilization on it which is good for my bipolar type 2.
So far, it hasn't worked for the symptoms I'm taking it for although it's working for others. That said, neurotrophy isn't a rapid process and things take time. 26 days are far from enough and I have to keep tolerance down meanwhile. I'll keep going.
This regimen is very nootropic already I don't feel the need to take any Noopept. I don't have brain fog anymore or any cognitive issues to speak of. Furthermore, my cognition is boosted beyond what's average to me. My mental fatigue is also reduced a little bit after dosing Cerebrolysin, but physically I still feel quite fatigued.
Polygala Tenuifolia + Cerebrolysin + Melatonin are doing all the heavy lifting. The only useless drug out of the list is actually 7,8-dihydoxyflavone. I think its bioavailability is too low even when taken sublingually. On the other hand, I feel Cerebrolysin quite strongly as it kicks in and it definitely works especially on 5 ml daily. That said, my started noticing tolerance to Cerebrolysin which means my dose of Polygala Tenuifolia wasn't enough to keep TrkB upregulated. I have since increased my Polygala Tenuifolia dose to 400 mg.
The libido improvements still persist despite the serotonergic effects of Polygala Tenuifolia.
The regimen has been changing my personality and behavior in subtle ways. Although it doesn't work for typical anhedonia and blunted affect (so far), it's bringing back the pre-PSSD procrastination, social anxiety and social anhedonia which means it's reducing cortical top-down control over the limbic system. The only drug that made me feel that way before was a D2/D3 dopamine agonist - which means this regimen is increasing limbic dopamine by a lot - although tonic release, not phasic, otherwise I'd have felt mood improvement and increased hedonic tone from it.
Although this regimen hasn't increased my hedonic tone (yet), I feel drastic mood stabilization on it which is good for my bipolar type 2.
So far, it hasn't worked for the symptoms I'm taking it for although it's working for others. That said, neurotrophy isn't a rapid process and things take time. 26 days are far from enough and I have to keep tolerance down meanwhile. I'll keep going.