I can say as a fun fact that when i reinstate SSRIs after not taking them for quite long time, i have window for like week or two, after which i go worse than my natural baseline, but i if i add inositol, like 50g a day, then i bounce back from crash to the window again. How long would it last i do not know, i suppose it just temporary increases PLC and Ca+2 signaling similar to the way fluoxetine did in the scientific work i linked on my original post.Meso wrote: ↑Sat Jul 17, 2021 3:36 pmI don't think it's that simple. You are onto something here for sure, but it's not the only root issue. There are several factors we must consider. Sex hormone receptors are methylated/silenced. I keep seeing people with normal testosterone levels yet they lack nocturnal erections and morning wood. Also, the genital numbness might be peripheral; a problem affecting the spinal cord, I reckon.
Either way, the only way we can know whether your hypothesis is solid is through good ol` trial and error. I appreciate the fact that you are trying this on yourself. Thank you for that. I always try things on myself to share with other members my reactions before they try it themselves.
That said, several of my patients have found relief with supraphysiological TRT + lithium + progesterone, through trial-and-error, which points towards methylation and sex hormone receptors' malfunction.
It's my fifth day so far, nothing interesting to report as of now. Pay attention to the fact that inositol on average took like 7 weeks to fully work.
Actually after more research i do not know if SSRI microdose with inositol trial would be more hopeful, i will do more research and come to decision if magnesium trial has to wait after summer and during summer i may try microdose SSRI with inositol, so far with magnesium there is nothing happening, nothing interesting to report, except the fact that i do not have extreme brain fog as i would have, if i took magnesium solo, it is still 5 day though. But initial response to SSRI+inositol was better. So i will try this and come to magnesium later, if this trial will not work. SSRI regulate https://en.wikipedia.org/wiki/SOC_channels function and they are responsible for Ca+2 reuptake, i am curious what will happen if during SSRI-mediated SOCS blockade i will increase cytosol Ca2+ from phospholipase mediated IP3 and RyR3 receptor stimulation. This trial will last 3 weeks, after which i will make an assessment and decide what to do.
Magnesium hypothesis comes from the idea that i tried to interconnect some of the inositol cures with component that is possible to be shared with those group of people who got cured from it, the decision comes from the proposition that what might vary between people is plasma level of various vitamins and minerals, then i researched various substances from that group to find if any of them has any interaction with IP3, DAG or intracellular Ca2+, after research i found that magnesium undergoes various interactions with both IP3 and Ca+2, but it was just a speculation, what was shared with these inositol cures is in fact that in cases where it cured PSSD, inositol was introduced with supplements that either raise serotonin levels, inhibit serotonin reuptake or induce serotonin release, so after extended research i came to conclusion that supplementing with SSRI is more hopefull way to go, as in one of the cured case it was supplemented alongside tramadol, which one of the mechanism is that it inhibits serotonin reuptake. I will write about ongoing sensual experiences during this treatment in this thread on a weekly basis. What is important that my PSSD manifest mainly in anhedonia and lack of emotions and imagination, i thought at some point it is actually my natural state of being, but after reinstating SSRI i experienced 100% relief in those symptoms for a brief moment, before things plateu and i got stuck with those symptoms again, which pointed me that in fact these things come from the fact that i have taken SSRI in the past.