In total the synaptic serotonin(and all the rest of it) was suppressed for about 4 weeks if you include the ~10 days it takes to renew the enzyme so I felt that if brain plasticity was to kick in it would have already done so.(when I took ADs it would take about 3 weeks to kick in)Meso wrote: ↑Sat Jul 17, 2021 4:07 pmFalse, we should still consider 5HT. This experiment is deeply flawed: First, like you said we have to take into account compensatory actions of the brain. When you take an SSRI, it takes a couple of months to work, this is because it works through the compensatory actions themselves (i.e. autoreceptors downregulation, BDNF upregulation, glutamate blunting, etc.). So, if you really want to move on from 5HT, you have to trial Fenclonine for at least a couple of months as well since we need to see how the compensatory counter-effect will be like.sylv wrote: ↑Sat Jul 17, 2021 6:58 am The effects are mild because brain is plastic and compensate the lack of serotonin signalling with other transmission. You see this things all the time in knouckout gene experiments. In neuroanatomy even removing entire lobe ( like in epilepsy ) gives limited symptoms, because - again - brain is plastic. The things go wrong and drastic only when you hit neural hub responsible for synchronizing other associative regions like the prefrontal cortex is.
Instead of looking to fix some isolated "dopamine deficiency" or "excessive serotonin" the question should be how a certain intervention will affect the whole neurocircuits which are made from many interconnected systems . Given the current state of knowledge only very weak assumptions could be made and these will mostly be wrong. From this experiment we know the elimination of 5HT is not the way to go
Second, we don't know the source he got his Fenclonine from. Is it lab-grade? or is it the very-likely scam that is on alibaba/amazon?
Third, before we move on from 5HT, several people has to repeat this trial. Scientific experiment doesn't allow room for n=1 anecdotes.
It was lab grade from a top US lab, 99.98% tested they even gave me the certificate, it was definitely the real deal and I could feel it(had to get creative to get them to sell it to me). Also the chemical properties were exactly as I had read, I even tested the solubility roughly.
It maybe would have been smart to keep going a bit but it was hard to tolerate at the end and it cost me $600 for this course.