Saccadic eye velocity test - Allopregnanolone

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cdraham
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Saccadic eye velocity test - Allopregnanolone

Unread post by cdraham »

Does anyone know how to get this done?


"Saccadic eye velocity is used to assess the effects of GABA-A receptor agonists such as allopregnanolone or benzodiazepines (Ball et al. 1991; Timby et al. 2006). The saccade is the fast movement of the eye when the gaze is shifted to a new peripheral visual stimulus. When a new visual target is presented, the gaze, after a latency period, moves towards the new target (Carpenter 2000). The maximal speed reached during the saccade, i.e., the SEV, is dependent on the angle between the targets, is regulated by the activity of the GABA-A receptor, and is not under conscious control (Ball et al. 1991). SEV is, therefore, a sensitive and quantifiable measure of GABA-A receptor modulation by compounds like allopregnanolone or benzodiazepines (Ball et al. 1991; Carpenter 2000; Moller et al. 2016; Timby et al. 2006). A GABA-A-mediated decrease in SEV, for example by allopregnanolone, is generally accompanied by increased sedation/somnolence (Timby et al. 2006; van Broekhoven et al. 2007)."

It could show if something is wrong with our GABA-a receptor.
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