Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

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throwaway
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Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by throwaway »

Got off a dozen SSRIs many years ago, slowly recovered, but recently crashed from trying a new supplement. Going on two days no sleep. Should I take trazodone for sleep? That's what the urgent care doctor offered. Or do you guys know any drugs/supps that will knock me out for sure? I've never been on trazodone.Thanks so much
Thomas
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by Thomas »

Could you please be more specific about your "new supplement"? Two days, that is nothing, your supplement should still be in your system.
IMHO, taking an AD only for insomnia is overkill. But if you are depressed and anxious (cf. your double-posting on the same subject), it may work.
Did you try sport and meditation?
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: loss of libido | anhedonia | sexual numbness
throwaway
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by throwaway »

Benfotiamine messed me up. Didn't know it affected serotonin before taking it.

"Benfotiamine reduced depression symptoms and improved mental function in mice by decreasing production of GSK3b. This triggers serotonin pathways that may reduce anxiety and help heal damaged brain cell connections." I took it cause I have a thiamine deficiency, not because I'm depressed.

I posted in different subforums thinking I'd get a variety of answers. Guess not.

A significant amount of Benfotiamine will stay in my system for 20 days since it's fat-soluble. I can't go without sleep that long. This reminds me of after cold turkeying the SSRI many years ago, except my only symptoms right now: insomnia, palpitations, hot flashes. The SSRI ran the gamut. If this is indeed a crash, then my sleep will take many months to normalize (if it even will). I'm hoping it's what you & urgent care doctor said, the insomnia will go away in a few days. As for now, doesn't hurt to ask around for advice/opinions from my fellow pssd sufferers.

Doctor prescribed hydroxyzine by the way. I'm not going to take it cause I heard antihistamines make you crash hard.
Thomas
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by Thomas »

Hydroxyzine is the usual drug for insomnia. It never worked for me (even pre-PSSD) but I have not read about anyone crashing with it and no one reported a crash on my topic about it.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: loss of libido | anhedonia | sexual numbness
throwaway
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by throwaway »

viewtopic.php?f=41&t=3695&p=34961&hilit=benadryl#p34961
Read last sentence of OP

viewtopic.php?f=10&t=3306&p=31953&hilit=benadryl#p31953
Read last post

viewtopic.php?f=20&t=3260&p=31614&hilit=benadryl#p31614
Second paragraph of OP

viewtopic.php?f=32&t=3236&p=31440&hilit=benadryl#p31440
OP

viewtopic.php?f=41&t=3235&p=31438&hilit=benadryl#p31438
Third paragraph of OP

Just use the search function.

Doctor also offered ambien & benzo but I get dependent on them to sleep the day after. Was offered propanonol but someone here said that's how they got PSSD in the first place.
arahant
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by arahant »

throwaway wrote:
Sun Sep 13, 2020 3:53 am
Got off a dozen SSRIs many years ago, slowly recovered, but recently crashed from trying a new supplement. Going on two days no sleep. Should I take trazodone for sleep? That's what the urgent care doctor offered. Or do you guys know any drugs/supps that will knock me out for sure? I've never been on trazodone.Thanks so much
I had the same issue and doubts. My Pdoc offered trazodone or hydroxyzine. I thought trazodone would be an overkill and tried hydroxyzine which worked.

It is highly sedative, and people confound it as "crash", which is such a generic and meaningless word used basically for venting purposes.

Be sure not jumping to catastrophic conclusions about a supplement you have taken like: it may take weeks or months to get out of my system.
This rumination can be on your mind longer than the supplement, and also messing with your sleep.

Then I started with very low doses, like 1/2 of 25 mg pill + relaxation exercises was enough to kick in within 2 hours.
It works as anti-serotonin too.

I had to stop because I was snoring a lot and it was "crashing" my marriage. :shock:
Thomas
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by Thomas »

throwaway wrote:
Sun Sep 13, 2020 5:22 am
Just use the search function.
Diphenhydramine is not Hydroxyzine. The only one talking about Hydroxyzine is not really specific about the crash.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: loss of libido | anhedonia | sexual numbness
throwaway
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by throwaway »

arahant wrote:
Sun Sep 13, 2020 9:48 am
Be sure not jumping to catastrophic conclusions about a supplement you have taken like: it may take weeks or months to get out of my system.
This rumination can be on your mind longer than the supplement, and also messing with your sleep.
Love this. I actually knocked out last night. Got 7 hours of sleep and feel much better.
Thomas wrote:
Sun Sep 13, 2020 11:43 am
Diphenhydramine is not Hydroxyzine. The only one talking about Hydroxyzine is not really specific about the crash.
Pretty sure why we might crash from taking Benadryl or Hydroxyzine is the anticholinergic properties.
Anticholinergics are a group of substances that blocks the action of the neurotransmitter called acetylcholine at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells.
The parasympathetic nervous system is one of three divisions of the autonomic nervous system. Sometimes called the rest and digest system, the parasympathetic system conserves energy as it slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gastrointestinal tract.
Difference between Sympathetic And Parasympathetic Nervous System. The sympathetic nervous system prepares the body for the “fight or flight” response during any potential danger. On the other hand, the parasympathetic nervous system inhibits the body from overworking and restores the body to a calm and composed state.
You can see how inhibiting the parasympathetic nervous system in a PSSD body can be detrimental right? That's what SSRI's did to us in the first place. SSRI's are anticholinergic.
Trazohell
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by Trazohell »

WTF dude don't take Trazodone, it give me and several others bad PSSD.
June 2015 - April 2016 Fluoxetine
April 2016 - March 2017 Fluvoxamine
December 2017 9 days Trazodone
After Trazodone PSSD: loss of libido & spontaneous/night/morning erections, prostate/pelvic pain, genital numbness, lower sperm count, Anhedonia
arahant
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Re: Have pretty bad insomnia after trying a new supplement. Should I take trazodone for sleep?

Unread post by arahant »

throwaway wrote:
Sun Sep 13, 2020 3:25 pm
arahant wrote:
Sun Sep 13, 2020 9:48 am
Be sure not jumping to catastrophic conclusions about a supplement you have taken like: it may take weeks or months to get out of my system.
This rumination can be on your mind longer than the supplement, and also messing with your sleep.
Love this. I actually knocked out last night. Got 7 hours of sleep and feel much better.
Thomas wrote:
Sun Sep 13, 2020 11:43 am
Diphenhydramine is not Hydroxyzine. The only one talking about Hydroxyzine is not really specific about the crash.
Pretty sure why we might crash from taking Benadryl or Hydroxyzine is the anticholinergic properties.
Anticholinergics are a group of substances that blocks the action of the neurotransmitter called acetylcholine at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells.
The parasympathetic nervous system is one of three divisions of the autonomic nervous system. Sometimes called the rest and digest system, the parasympathetic system conserves energy as it slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gastrointestinal tract.
Difference between Sympathetic And Parasympathetic Nervous System. The sympathetic nervous system prepares the body for the “fight or flight” response during any potential danger. On the other hand, the parasympathetic nervous system inhibits the body from overworking and restores the body to a calm and composed state.
You can see how inhibiting the parasympathetic nervous system in a PSSD body can be detrimental right? That's what SSRI's did to us in the first place. SSRI's are anticholinergic.
Great that you slept 7 hours. Regarding proper sleep, parasympathetic stimulation is fundamental, the parasympathetic nervous system is responsible to induce relaxation and resting state. Even diaphragmatic breathing, progressive muscular relaxation, mindfulness is known to induce relaxation. But sometimes the fight and flight state is so strong that's difficult to sit to do an exercise which takes around 20 min to kick in.
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