PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

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capitalCK
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PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by capitalCK »

Hi - I've Post Accutane Syndrome and Post Finasteride syndrome. Quick background:

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2015 (age 31): Accutane (3 months). Soon after erectile dysfunction, brain-fog and emotional detachment/flatness. 
- Urologist prescribed Cialis/Viagra and they worked well. 
Brain fog continued.
Emotional flatness/detachment disinterest continued.
(I never made the connection to Accutane side-effects).

2017: Hypothyroid, high cholesterol, brain fog and low testosterone. Doctor prescribed Synthroid and Crestor and TRT (weekly Testosterone + HCG + anastrozole). 
- Within minutes of starting Synthroid, brain fog disappeared. And even today no brain fog anymore.
- Sexual issues did NOT resolve, still needed Cialis/Viagra.
(again, still didn't make connection to previous Accutane use).

2018: Hair transplant, doctor gave me Minoxidil and Propecia. 
- Within a month of using that, Cialis STOPPED working.
Went to few doctors, did many tests and treatments (like penile doppler, ultrasounds, brain pituitary MRI, ShockWave therapy) - nothing wrong was found nor any treatment worked.

2019: Stopped TRT because it wasnt doing anything and I got tired of injecting every week.
- Continued taking Synthroid, Crestor (EOD).

2020:  Discovered PropeciaHelp, PFSFoundation, PSSDforum, HackStasis, RayPeat, forums, Area 1255 blog while searching and learnt that:
(A.) I probably had Post Accutane Syndrome in 2015. It blocks 5ar1 enzymes but not 5ar2. So, my body was partially OK.
(B.) Finasteride+MInoxidil block 5ar type 2 enzymes that probably gave me Post Finasteride Syndrome.


My major problems remaining right now:
A) Do not respond to Cialis/Viagra. Injections like Quadmix seem to work but not practical for me. Also, no mental horni-ness/libido accompanying Quadmix erection.

B) can get hard with physical stimulation but lose erection quickly

C) Rick Simpson Oil/THC oil gives erection

D) Sometimes able to masturbate (especially after taking 1ml of THC oil) to porn but orgasm takes VERY VERY long and is not pleasurable, and volume is very low too.

E) Short-term memory decline

F) emotional-flatness has improved but still not baseline


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Now, I'm tired of doctors telling me it is all in my head. So, I'm trying to treat myself.  And I'd appreciate some guidance.




I think I need to take care of following things for recovery:

1. Boost 5ar type 1 enzyme somehow, this will bring back neurosteroids like Allopregnanolone back online. I'm assuming there is a deficit of it.
2. Boost 5ar type 2 enzyme somehow, this will bring back Androgens like DHT online.
3. Heal Gut as both Accutane and Finasteride destroy gut lining and microbiome
4. Balance Neurotransmitters
5. Re-establish Nitric Oxide sensitivity
6. Reverse epigenetic modification caused by Finasteride/Accutane as confirmed by many studies
7. Optimize vitamins/minerals


I've some how to address some of the above and NEED YOUR GUIDANCE!

1. Boost 5ar 1:
Not sure how. I've started taking 2-3mg of 5a-DHP drops. Hopefully, that will be a positive feedback loop and force the body to produce more 5ar1.
-> Take HCG 250iu 3x a week

2. Boost 5ar 2:
Started Proviron and HCG (no Testosterone). DHT has a positive feedback loop so this should stimulate the body to produce more 5ar2 enzymes.

3. Heal Gut:
-> BPC-157 injection as well as oral
-> Consume Probiotic supplements, Kefir, Yogurt

4. Balance Neurotransmitter: (urine test results attached):
I seem to be high on Dopamine, medium on Serotonin and low on Histamine, Epinephrine, Norepinephrine, GABA, Glutamate

4a. for GABA:
-> Bacopa to re-sensitize GABA receptors
-> Shilajit to counter serotonin increase that comes from Bacopa

4b. for Glutamate:
-> L-Glutamine
-> perhaps D-Aspartic Acid

4c. for Epinephrine and Norepinephrine:
-> Since I'm already high on Dopamine, I need to promote its metabolism into Epi and Norepi:
-> Magnesium, Vitamin C
-> perhaps SAM-e too but not sure

4d. for Histamine:
-> L-histidine
-> Maca (but this may also increase Dopamine further, not sure, need your feedback)

5. Re-sensitize Nitric Oxide sensitivity:
-> Horny Goat Weed, Trans-Resveratol, Butea Superba, Cialis/Viagra
Area1255 blog talks about upregulating Dopamine receptors etc but since my Dopamine is already high, not sure if this is the right thing to do for me. Please HELP

6. Reverse epigenetic modifications:
No sure way of doing this. But:
-> water fasting 48 hours, once every 2 weeks
-> Sodium Butyrate and Sodium BHB daily

7. Optimize vitamins/minerals:
-> Vitamin A, E (liver oil based)
-> B complex (methylated ones)
-> Vitamin C
-> Magnesium (glycinate, magetin)
-> Zinc + copper combo (Jarrow's)
-> Trans-Resveratrol
-> Ginkgo Biloba



Various blog posts talk about:
- Yohimbine
- Forskolin
- DXM
- Dopamine upregulation
- Wild jujube extract
- NMDA upregulation
- Glutamate sensitivity

Not sure where to fit in these. In fact, I'm not EVEN sure if the 7 steps I've listed above are even right and if I'm addressing them correctly. 


Thanks for reading such a long post! I hope to receive some guidance/feedback from you.



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naiverat
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by naiverat »

Considering we still don't fully understand the mechanisms underlying any of these conditions -- just hypotheses -- it's very hard to critique your proposed regimen.

With that said, best of luck with whatever you try. Keep a log and keep us updated on the outcomes!
Fluoxetine Jan. '16 - Aug. 16'. Low libido, weak erections, CNS dysfunction, anhedonia

Windows on the following: Inositol, choline, NAC + Histidine, MSM, SJW, L-Arginine, Sildenafil, Naltrexone, boron
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capitalCK
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by capitalCK »

Thanks.

The person that writes Area1255 blog - is he in this forum?

He has a post "How to Become Sensitive to Nitric Oxide Sups Again (Regain Sensitivity to N.O Products / Make N.O Products Work Again)" - I am wondering how that can fit in with me? Given that I already have high dopamine (Test results in first post).

And also, I am going to quote this from blog post - can someone explain this? I'm confused:
1. Take DXM (dextromethorphan) or Memantine to upregulate the NMDA-receptors; to restore the Nitric Oxide pathway. [study 1] [study 2]
2. Take Risperidone; an antipsychotic for 1-week to upregulate the Dopamine D2-receptors; as they are needed for erections etc [upregulation study] [D2 & Erections]
3. Find a source and buy LECOZOTAN - a unique 5-HT1A antagonist which should block the post-synaptic receptors and restore nerve sensations and spinal connections.
Does it mean to take all three (of the above) or only one?

Finally, I'm not sure what antagonizing 5-HT1A receptor does. I mean, in the immediate term it blocks the effect of Serotonin. But wouldn't that cause your brain to synthesize even more Serotonin?
Last edited by capitalCK on Tue Sep 08, 2020 6:46 pm, edited 2 times in total.
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Twentyoneguns
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by Twentyoneguns »

Looks like your TSH is really now, indicating an overactive thyroid, though your T4 is in range, I wonder what your TSH was before Synthroid? Excellent that you had positive results. My TSH was slightly raised at 5.7, but taking Levothyroxine didn’t shift it at all, doctor lost interest.
My TSH seemed to spike after a series of stressful events two years post developing PSSD. Its on its way back down naturally. I also gave up on Soy milk which is said to affect thyroid function.
Maybe be careful with Ginkgo Biloba, I could not reach orgasm after just one dose! Returned to baseline after about a week.
Good luck.
Male
PSSD after 3 days on Sertraline (50mg) (Aurobindo) December 2016 to date.
Tinnitus, insomnia (1.5 hours/night sleep) poor memory/cognition as a bonus!
Possibly PSSD from October 1998...just didn't realise what I was suffering from! (pre internet)
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capitalCK
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by capitalCK »

Twentyoneguns wrote: Tue Sep 08, 2020 2:21 pm Looks like your TSH is really now, indicating an overactive thyroid, though your T4 is in range, I wonder what your TSH was before Synthroid? Excellent that you had positive results. My TSH was slightly raised at 5.7, but taking Levothyroxine didn’t shift it at all, doctor lost interest.
My TSH seemed to spike after a series of stressful events two years post developing PSSD. Its on its way back down naturally. I also gave up on Soy milk which is said to affect thyroid function.
Maybe be careful with Ginkgo Biloba, I could not reach orgasm after just one dose! Returned to baseline after about a week.
Good luck.
My TSH is really low because of Synthroid that I take. Nothing to do with overactive thyroid, it is actually under-active (which I suspect has something to do with Accutane - I got Cholestrol, Thyroid issues few months after finishing Accutane). Prior to Synthroid, my TSH was tested multiple times to be sure and it ranged from about 5.5-6

For you, some people's body don't convert to t4 to t3 well and so even if you take Synthroid, your TSH might be raised. For those people, there is a different med Cytomel. To be sure, get your TSH, T4, Free T4, T3, Free T3 and Reverse T3 - all of them tested. And probably Thyroid antibodies too (to rule out Hashimoto). That'd give you a clear picture of the problem. TSH alone doesnt say much.
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Twentyoneguns
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by Twentyoneguns »

Thanks for your reply. I've now read up on this and will chase it up with my doctor. Interesting that your TSH was only around 5.5 (about the same as mine) and that you experienced such good results with Synthroid. My sister had her thyroid removed due to cancer and she has to have her levels finely tuned to stay feeling well...shows how important this is.
Male
PSSD after 3 days on Sertraline (50mg) (Aurobindo) December 2016 to date.
Tinnitus, insomnia (1.5 hours/night sleep) poor memory/cognition as a bonus!
Possibly PSSD from October 1998...just didn't realise what I was suffering from! (pre internet)
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capitalCK
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by capitalCK »

capitalCK wrote: Tue Sep 08, 2020 1:58 pm Thanks.

The person that writes Area1255 blog - is he in this forum?

He has a post "How to Become Sensitive to Nitric Oxide Sups Again (Regain Sensitivity to N.O Products / Make N.O Products Work Again)" - I am wondering how that can fit in with me? Given that I already have high dopamine (Test results in first post).

And also, I am going to quote this from blog post - can someone explain this? I'm confused:
1. Take DXM (dextromethorphan) or Memantine to upregulate the NMDA-receptors; to restore the Nitric Oxide pathway. [study 1] [study 2]
2. Take Risperidone; an antipsychotic for 1-week to upregulate the Dopamine D2-receptors; as they are needed for erections etc [upregulation study] [D2 & Erections]
3. Find a source and buy LECOZOTAN - a unique 5-HT1A antagonist which should block the post-synaptic receptors and restore nerve sensations and spinal connections.
Does it mean to take all three (of the above) or only one?

Finally, I'm not sure what antagonizing 5-HT1A receptor does. I mean, in the immediate term it blocks the effect of Serotonin. But wouldn't that cause your brain to synthesize even more Serotonin?

Can anyone help with this? I am unsure how this 3 step protocol work to restore Nitric Oxide signaling.
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kpavel
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by kpavel »

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capitalCK
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by capitalCK »

wow,
Thanks so much @Kpavel!
finities infinities
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Re: PAS/PFS/PSSD treatment, critique and correct, Please! (Test Results Attached)

Unread post by finities infinities »

Avoid any methyl donors. I found out for myself what they are doing with me. But at least I know what caused my problem 3 years ago.
Cannabigerol is strong alpha 2 agonist, and downregulate this in long term use, this is bad for society life. Low alpha2 ( high norepinephrine) create very empathetic, emotional, morality disgust, and rage, PTSD like state. Alpha 2 blunt emotion/empathy and emotional memory and induce sexy masculine blunting feeling.
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