Postsynaptic 5HT1AR: worth re-exploring (trial)

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Halan
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Re: Postsynaptic 5HT1AR: worth re-exploring (trial)

Unread post by Halan »

fellow1 wrote: Thu Sep 17, 2020 7:25 am
Halan wrote: Wed Sep 16, 2020 10:15 pm "Within both SERT+/+ and SERT–/– rats the potency of F-13714 was much stronger compared to F-15599."

F-13714 is a preferential 5-HT1A autoreceptor agonist
F-15599 is a preferential 5-HT1A heteroreceptor agonist
so are there any accessible analogues like F-13714 ?
Both worked and are 5-ht1a agonists
Buspirone is a 5-ht1a agonist that is avaiable. I think it's a weak agonist, correct me if I'm wrong.
Gepirone would be better cause its effects on D2 receptors are negligible, unlike buspirone.

I think buspirone would work in doses like 40mg~60mg/day and after some weeks of use.
If it doesn't work, IMO a 5-ht1a antagonist like cannabigerol (CBG) is worth exploring. Anything aiming 5-ht1a and/or SERT is worth a shot.

I'm trying to get my hands on buspirone, but my doctor denied. This is frustrating cause I need to wait months till an appointment.
arahant
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Joined: Tue Nov 26, 2019 11:54 am
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Re: Postsynaptic 5HT1AR: worth re-exploring (trial)

Unread post by arahant »

Halan wrote: Thu Sep 17, 2020 5:49 pm
fellow1 wrote: Thu Sep 17, 2020 7:25 am
Halan wrote: Wed Sep 16, 2020 10:15 pm "Within both SERT+/+ and SERT–/– rats the potency of F-13714 was much stronger compared to F-15599."

F-13714 is a preferential 5-HT1A autoreceptor agonist
F-15599 is a preferential 5-HT1A heteroreceptor agonist
so are there any accessible analogues like F-13714 ?
Both worked and are 5-ht1a agonists
Buspirone is a 5-ht1a agonist that is avaiable. I think it's a weak agonist, correct me if I'm wrong.
Gepirone would be better cause its effects on D2 receptors are negligible, unlike buspirone.

I think buspirone would work in doses like 40mg~60mg/day and after some weeks of use.
If it doesn't work, IMO a 5-ht1a antagonist like cannabigerol (CBG) is worth exploring. Anything aiming 5-ht1a and/or SERT is worth a shot.

I'm trying to get my hands on buspirone, but my doctor denied. This is frustrating cause I need to wait months till an appointment.


The whole azapirone family is full of 5-HT1A agonists.

https://en.wikipedia.org/wiki/Azapirone


Usually, the issue is that doctors doctors don't like patients asking for a given drug.
I have been working alongside MDs for more than decade, it does not sound good a patient suggesting a drug.
It looks like the patient self-diagnosed an issue, but skips their medical advice by just asking for a drug which was not a medical decision after their reasoning.

I think I was lucky because I just described my history of sertraline use and symptoms, and my p-doc prescribed buspirone after trying higher doses of Buproprion.
I had not heard about buspirone before I got this prescription.
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
PsychoGenesis
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Re: Postsynaptic 5HT1AR: worth re-exploring (trial)

Unread post by PsychoGenesis »

buspirone / gepirone can make LSD less effective it seems
https://pubmed.ncbi.nlm.nih.gov/1973935/
Last edited by PsychoGenesis on Sat Oct 24, 2020 11:22 am, edited 1 time in total.
arahant
Posts: 564
Joined: Tue Nov 26, 2019 11:54 am
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Re: Postsynaptic 5HT1AR: worth re-exploring (trial)

Unread post by arahant »

The hacktasis link seems to be broken. It's not opening here.
Wellbutrin (2007 - 2018)
Wellbutrin + Sertraline (2015)
Wellbutrin + Ritalin (2016 - 2018)
Wellbutrin + Ritalin + Sertraline (3 months in 2018)
Buspirone (Feb 2019 - Today)
Ritalin + Buspirone (Nov 2019 - today)
cdraham
Posts: 448
Joined: Thu Jul 04, 2019 10:39 am
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Re: Postsynaptic 5HT1AR: worth re-exploring (trial)

Unread post by cdraham »

I think the only way would be lowering central serotonin while upregulating 5HT1A at the same time - while not getting any increase in serotonin or 5ht1a activation in that time frame.
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