Re: Cure attempt #2 (in-progress / initial findings)
Posted: Thu Nov 14, 2019 8:07 am
Added Update #4
[Update 4]
14-11-2019 (Day-Month-Year)
Right. So it's been a while and I have good news and bad news.
NMDAR signaling is starting to reach a stable baseline. I'm noticing more emotions and hedonistic response returning, but i still need to focus on downregulating NMDAR beyond baseline. For this, the best solution is TrkB receptor upregulation + BDNF boosting - as this can downregulate NMDAR.
Cognitive symptoms are currently the worst. Without Rasagiline + Donepezil, I experience intense brainfog and aberrantly prolonged sleep inertia. My long-term and short-term memory are senile-like mild dementia. Since I'm looking into a permanent cure for my PSSD instead of symptomatic relief, it doesn't make sense returning to these drugs. The best solution is, therefore, TrkB receptor upregulation + BDNF boosting to restore limbic integrity, boost hippocampal neurogenesis, upregulate dopamine receptors, and improve glutamate firing.
The only drugs/supplements I know of that can upregulate TrkB receptors to a significant degree are Metformin, Schisandra, Semax, and Genistein. Other things are weak (i.e. Forskolin and niacin). For TrkB receptor upregulation and BDNF boosting, I'll take:
- 500 mg Metformin. (+ Ubiquinol and cyano-B12, since Metformin can lower those)
- 500 mg Schisandra.
I won't start taking these right away since they are expensive and I can't buy them at the moment. I didn't even buy l-cirulline yet. (currently in the middle of moving out, and that costs too much). Schisandra can be replaced by N-Acetyl-Semax, but I have no access to it (won't pass through customs).
What about sexual function?
I have been having sex on a daily basis - sometimes twice a day. But I'm noticing that my refractory period is getting longer and longer each time. Orgasm-mediated mu activity is probably reversing some of the AR upregulation that took place in the mPOA - especially since my orgasms are much more intense than pre-PSSD = much more robust mu activity.
Don't be alarmed though, this worsening is mild and likely transient. Probably I just need to skip sex for a couple of days. I still crave the female body form and find it mesmerizing to look at. So it's not that bad. I wish I can return to pre-PSSD level where refractory period was only 10 minutes, though. I've also noticed that on days I have 2 orgasms, the following day I wake up with no morning wood.
This means that my AR signaling has recovered a lot but it's still not at an optimal level. Too many orgasms without taking any break might be enough to reverse some of the permanent sexual benefits. I'm currently researching ways to boost AR signaling with excellent leads (you can find more info on my Discord server: https://discord.gg/Mej6ct9).
New baseline (so far):
Libido: 9/10
Erections: 9/10
Orgasms: 12/10 (Better than pre-PSSD)
Hedonistic response: 4/10
Emotional response: 4/10
Cognition: 3/10
I doubt that it would improve further than this without NMDAR downregulation and TrkB receptor upregulation.
Random tidbits:
Speaking of emotions/hedonistic response, I have to say I noticed that when I'm enjoying music, I feel perfectly content listening to it that I have no desire for watching a TV series or playing a game. It's a little strange.
GAD is also no where to be found despite of the mild improvement in emotional response. I still have diarrhea and IBS so I guess it isn't related to GAD after all.
Dreams are extremely vivid and deep. Almost daily wet-dreams or sex-themed dreams, but overall having very bizarre themes. It's like tripping while asleep.
That's all for this update.