Cure attempt #2 (in-progress / initial findings)

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PsychoGenesis
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Re: Cure attempt #2 (in-progress / initial findings)

Unread post by PsychoGenesis »

did you frontload memantine?
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Meso
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Re: Cure attempt #2 (in-progress / initial findings)

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PsychoGenesis wrote:did you frontload memantine?
I'm on Memantine to keep the NMDA rebound minimal. It's overall useless to antagonize NMDAR now. Instead, my focus will be to downregulate it beyond baseline - possibly via targeting dopamine receptors.
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Meso
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Re: Cure attempt #2 (in-progress / initial findings)

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I have good news.

To confirm my NMDA receptors excessive signalling causing my blunted affect - I have ingested 1200 mg NAC just an hour ago.

As soon as it kicked in, full emotional spectrum has returned. Which means the DXM benefits might have actually stuck emotion- and hedonistic-wise, and they were simply covered up by the excessive NMDA rebound signalling/upregulation.

I'm listening to music now with wife, eyes full of tears, and hugging her.

NAC never did this before DXM trial, which means DXM benefits might have actually stuck regarding emotions/hedonism too.

Only time will tell!!
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PsychoGenesis
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Re: Cure attempt #2 (in-progress / initial findings)

Unread post by PsychoGenesis »

whoa that is a great find for the community, I'm anxious to see if i can replicate it as soon as i finish my current protocol

i always frontload memantine to upregulate nicotinic receptors and get the benefits from day 1without the initial brain fog period

I don't like chronic NAC or metformin because they impair exercise-induced adaptation but hey, maybe a course of a few days is enough to shift things up and stabilize a new baseline

do you intend to keep taking it??
finities infinities
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Re: Cure attempt #2 (in-progress / initial findings)

Unread post by finities infinities »

I am very happy that we are in a similar situation now! So our joint work will be based on dopaminergic? I tryed metergoline (serotonin antagonist + D2 agonist) caused a similar reaction to NAC in you. NAC is N-acetyl carnitine? This is NMDA antagonist?
mrstaircase
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Re: Cure attempt #2 (in-progress / initial findings)

Unread post by mrstaircase »

Mesolimbo wrote:I have good news.

To confirm my NMDA receptors excessive signalling causing my blunted affect - I have ingested 1200 mg NAC just an hour ago.

As soon as it kicked in, full emotional spectrum has returned. Which means the DXM benefits might have actually stuck emotion- and hedonistic-wise, and they were simply covered up by the excessive NMDA rebound signalling/upregulation.

I'm listening to music now with wife, eyes full of tears, and hugging her.

NAC never did this before DXM trial, which means DXM benefits might have actually stuck regarding emotions/hedonism too.

Only time will tell!!
Isn’t this just the infamous sulfuric response to pssd?
This works every so often to get full relief for a couple of days.

Give MSM a try instead of NAC
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Meso
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Re: Cure attempt #2 (in-progress / initial findings)

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mrstaircase wrote:
Isn’t this just the infamous sulfuric response to pssd?
This works every so often to get full relief for a couple of days.

Give MSM a try instead of NAC
I had been taking MSM a year ago for joint pain. It neither had a profound effect on my joint pain nor on PSSD so I quit.
I also tried NAC several times before, no effect on PSSD.

It's highly improbable that this is a sulfuric window, but it's not impossible.

That said, I lost my emotions again when NAC wore off and now I have benzo withdrawal-like irritability and symptoms. I'm pretty sure it's a NMDAR signaling problem.

It's a game of waiting now. Waiting for NMDAR to return to baseline activity and then figuring out a way to downregulate NMDAR further to fix my PSSD once and for all.
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Meso
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Re: Cure attempt #2 (in-progress / initial findings)

Unread post by Meso »

Nice find, thanks for sharing!
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finities infinities
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Re: Cure attempt #2 (in-progress / initial findings)

Unread post by finities infinities »

It is a great hope for me! Because I probably also have a problem with upregulate NMDAR. In general, schizophrenics have too little this receptor activity and symptoms - magical, irrational, superstition, religious. (opposite to me). I also noticed that in psychiatric hospitals people after neuroleptics have a similar condition to me - from what I learned is neuroleptics through D2 antagonist increase NMDA acitivity and create anhedonia, overthinking, anxiety, to much rational thought type me?
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