SJW Always Cures My PSSD- kramdrol OP

Post any data on Treatments and experimentation.
defmyst
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by defmyst »

squirtleSquirtle wrote: Tue Jul 14, 2020 7:05 pm I have been meaning to post a little summary of the experiment for a while now, but haven't found the time to really sit down and say everything there is to say. Instead of delaying further I figured I would just post a functional summary for now and describe the details more fully in my own words on PSSDDDrugsAndRockAndRoll perhaps by next week.

I started SJW (Jamieson brand with standardized to 3% hyperforin and 0.3% hypericin) on December 18th 2019. You can go through the detailed logs I made in the thread in the thread to get the details on the dosing I took until getting up to my steady dose. From February 2020 until today I was taking 200 mg x 2 daily (one morning, one before bed). Here is the steady state SJW state I reached for all of that time.

Experimental Summary:

PSSD Baseline (January 5, 2016 - December 18, 2019):
------------------------------------------------------
Erection Hardness: 3/10
Erection Ease: 2/10
Erection Duration: 1/10
Pelvic Floor Relaxation for Erection: 1/10
Libido: 1/10
Orgasm Intensity: 5/10
Ejaculatory Volume: 2/10
Ejaculatory Viscosity: 3/10
Ejaculatory Force: 1/10
Morning wood frequency: 1/10 (I did not get morning wood at all for 4 years of PSSD)


SJW Steady State:
------------------------------------------------------
Erection Hardness: 7.5/10
Erection Ease: 6/10
Erection Duration: 3/10
Pelvic Floor Relaxation for Erection: 7/10
Libido: 4/10
Orgasm Intensity: 8/10
Ejaculatory Volume: 7/10
Ejaculatory Viscosity: 6/10
Ejaculatory Force: 7/10
Morning wood frequency: 7/10 (I notice getting morning wood very frequently now)

Overall this has been a very successful experiment that has transformed my outlook in a wide variety of ways. Keeping an erection without stimulation is currently the weakest point to my sexual health, but even without PDE5 inhibiting drugs I have regained the basic functional capability to enjoy sexual intimacy. My sexual health is still far from normal but is no longer absent in a binary sense. I am not "cured", but the current state of affairs is significantly more manageable than PSSD baseline

Additionally, I have not noticed any negative side effects from SJW since the early days of this experiment. As mentioned, I will detail my experiment further in a video on PSSDDrugsAndRockAndRoll in the near future.

Squirtle Squirtle!
-Squirtle

Link to PSSDDrugsAndRockAndRoll: https://www.youtube.com/channel/UCn8GM6 ... subscriber
Were you taking anything else throughout this period or only SJW?
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squirtleSquirtle
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by squirtleSquirtle »

Nothing else on a consistent basis. I experimented here and there with (a month or so each with)
-watermelon
-zinc
-licorice root
-Maca
but have taken none of them for over two months now (lol except some watermelon on a hot summer day... but not eating a whole half melon/day as I was back in March).

The SJW is the only substance I have taken with ANY consistency and is most definitely the sole cause of my significant improvements.

Squirtle Squirtle!
-Squirtle

Link to PSSDDrugsAndRockAndRoll, the home of PSSD on youtube!
https://www.youtube.com/channel/UCn8GM6 ... subscriber
20 mg Prozac, March-May, Septemeber-December 2015
Problems starting at discontinuation: very low libido, erectile dysfunction, watery semen, no morning wood
Current Problems: mild erectile dysfunction
IHateProzac
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by IHateProzac »

Is it safe to use SJW & PED5i (particularly sildenafil) on the same day?

also,

Does SJW boosts or reduces the efficacy of sildenafil?
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squirtleSquirtle
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by squirtleSquirtle »

IHateProzac wrote: Wed Aug 12, 2020 8:09 am Is it safe to use SJW & PED5i (particularly sildenafil) on the same day?

also,

Does SJW boosts or reduces the efficacy of sildenafil?
There is always significant risk with a combining drugs that have not been carefully studied for interactions... especially something like SJW which has MANY mechanisms of action in both the liver and brain.

I did get curious about this myself however and decided to accept the risks a month ago and tried 15 mg of sildenafil in combination with the 200 mg of SJW extract I have tapered down to. The effects were terrifying. I had blurred vision and significant light sensitivity that took the over 3 weeks to improve back to what appears to be my normal vision thankfully. I am seeing an ophthalmologist in two weeks to formally make sure my vision is back to tip top shape.

Long story short... PDE5 inhibitors can be very dangerous drugs under the right circumstances... and there are always risks to consider when combining them with other drugs like SJW. I have decided I will never use a PDE5 inhibitor again after this experience and simply stay on SJW (which is working for me remarkably well) and eat watermelon daily.

Check out the PSSD youtube channel PSSDDrugsAndRockAndRoll!
https://www.youtube.com/watch?v=hYZe1sm ... 7Tb6zEgbkS

Squirtle Squirtle!
-Squirtle
20 mg Prozac, March-May, Septemeber-December 2015
Problems starting at discontinuation: very low libido, erectile dysfunction, watery semen, no morning wood
Current Problems: mild erectile dysfunction
PsychoGenesis
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by PsychoGenesis »

squirtleSquirtle wrote: Tue Jul 14, 2020 7:05 pm

SJW Steady State:
------------------------------------------------------
Erection Hardness: 7.5/10
Erection Ease: 6/10
Erection Duration: 3/10
Pelvic Floor Relaxation for Erection: 7/10
Libido: 4/10
Orgasm Intensity: 8/10
Ejaculatory Volume: 7/10
Ejaculatory Viscosity: 6/10
Ejaculatory Force: 7/10
Morning wood frequency: 7/10 (I notice getting morning wood very frequently now)



Link to PSSDDrugsAndRockAndRoll: https://www.youtube.com/channel/UCn8GM6 ... subscriber
any updates on your baseline, squirtle?? even if small
PsychoGenesis
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by PsychoGenesis »

some random tidbits

hyperforin

http://www.swisstargetprediction.ch/res ... mo_sapiens

hypericin

http://www.swisstargetprediction.ch/res ... mo_sapiens
------

according to the wikipedia pharmacodynamics hyperforin at more than 9mg or 1 tablet of perika at a time starts inhibiting the 5ht transporter

https://en.m.wikipedia.org/wiki/Hyperforin
Last edited by PsychoGenesis on Mon Oct 12, 2020 12:16 pm, edited 1 time in total.
PsychoGenesis
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by PsychoGenesis »

cdraham wrote: Fri May 08, 2020 2:53 am
Flobrade wrote: Thu Apr 30, 2020 5:35 pm Not yet, but i made great improvements and improve daily. I think running is crucial to success and it's underrated considering it upregulates 5ht1a in raphe nuclei which is the main problem of pssd.

@edit
What need to be understood that recovery is very personal timewise. For beetlebum it was moderately short, but perhaps his case was not that bad, as he experienced windows in first week of sjw treatment. I did experience windows, but it took me about a month, for someone else it might be 3 months, nonentheless running gradually increased both quantity and quality of windows. There were days where i was literaly floating in 'fairy-tale aura', something which i didn't experience even as a kid
How can you explain the cognitive symptoms/anhedonia with this theory? Im sure my 5ht2a receptors are affected in some way because i dont react much to psychedelics (5ht2a agonists), or maybe something else is wrong.

First time i took SJW it inproved my genital numbness partly but i quit after few weeks, I read it made some worse.
5ht1a autoreceptor desensitization blocked LSD effects

btw, 5ht2 receptor theory of psychedelics is kinda bullshit

*Ray, T.S. 2017. Mental Organs and the Breadth and Depth of Consciousness. Transform Press. June 27, 2017. Video, PowerPoint, & Manuscript
PsychoGenesis
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by PsychoGenesis »

Flobrade wrote: Thu Apr 30, 2020 5:28 pm ''5ht2a receptors increase dopamine in ventral tegmental area to set dopamine to nucleus accumbens which might explain why people experience windows. 5ht2a is positively regulating another neurotransmitter called glutamic acid, which is the most abundant neurotransmitter in the brain, appearing in approximmately 70% of neurons .

it also inhibits dopamine release in the striatum through gaba interneurons > (Stahl, 2013)
PsychoGenesis
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Re: SJW Always Cures My PSSD- kramdrol OP

Unread post by PsychoGenesis »

https://pubmed.ncbi.nlm.nih.gov/12905103/

seems like SJW and 5-ht2 interaction is contradictory
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