Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
Hi guys, I have a question about enzymes. See this picture:
What happens if here you example increase or decrease 3a HSD
Is progesterone affected too?
This is not specific to SSRIs (which target a specific part of 3a HSD enzyme as I know), I mean in general what happens when you decrease/increase 3a-HSD, the whole thing
What happens if here you example increase or decrease 3a HSD
Is progesterone affected too?
This is not specific to SSRIs (which target a specific part of 3a HSD enzyme as I know), I mean in general what happens when you decrease/increase 3a-HSD, the whole thing
Last edited by cdraham on Mon Aug 23, 2021 1:07 pm, edited 1 time in total.
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
You’re on the right track, in my opinion. The real cause of PSSD is caused by alterations to 3a-HSD. There is no doubt at this point, that PSSD is caused by methylated sex hormones and neurosteroids. I will try to find the answer to this.
Anybody who thinks 5HT1A receptors are involved in PSSD need to be kicked out of this forum. Androgens are the key to solving PSSD.
You are on the right track. Look at all the recoveries, and I don’t refer to those brainwashed morons who take half a pill of SJW and claim they are cured of a multi-systemic and multi-factorial illness, like PSSD.
Nevertheless, other than the fact that Finasteride users experience anxiety, while our anxiety is muted (potentially because our Allopregnanlone has been methylated, and increased, whereas those who take Finasteride have less of it). Every other symptom is exactly the same - dry skin, low libido, muscle loss, weight gain or loss, low body temperature, lack of dreams, anhedonia, penile shrinkage, hair shedding, genital numbness, penile rotation or curvature, brain fog, and the list goes on.
PSSD and PFS are strictly related to androgens and neurosteroids. I urge those in the PSSD community to give up the nonsensical theories on Serotonin, and focus on actually fixing the underlying mechanism which is - methylated sex hormones.
Let’s take a look at some of the most recent recoveries:
1) Meso: TRT + Lithium
2) TalkingAnt: Healthy Lifestyle + TRT/HCG
3) Bigmum: CDSNuts Protocol
4) MrStaircase: Androgenic Herbs + Clomid
Anybody who thinks 5HT1A receptors are involved in PSSD need to be kicked out of this forum. Androgens are the key to solving PSSD.
You are on the right track. Look at all the recoveries, and I don’t refer to those brainwashed morons who take half a pill of SJW and claim they are cured of a multi-systemic and multi-factorial illness, like PSSD.
Nevertheless, other than the fact that Finasteride users experience anxiety, while our anxiety is muted (potentially because our Allopregnanlone has been methylated, and increased, whereas those who take Finasteride have less of it). Every other symptom is exactly the same - dry skin, low libido, muscle loss, weight gain or loss, low body temperature, lack of dreams, anhedonia, penile shrinkage, hair shedding, genital numbness, penile rotation or curvature, brain fog, and the list goes on.
PSSD and PFS are strictly related to androgens and neurosteroids. I urge those in the PSSD community to give up the nonsensical theories on Serotonin, and focus on actually fixing the underlying mechanism which is - methylated sex hormones.
Let’s take a look at some of the most recent recoveries:
1) Meso: TRT + Lithium
2) TalkingAnt: Healthy Lifestyle + TRT/HCG
3) Bigmum: CDSNuts Protocol
4) MrStaircase: Androgenic Herbs + Clomid
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
I agree with melcangis research of neurosteroids beeing low, its likely why DHP is high and then progesterone is high too, several measured high progesterone here so this fits quite well.
Low neurosteroids should lead to anxiety, many of us have total absence of anxiety so i think there is more going on. I think the short lived windows ppl see on low dose ssri reinstatement could be because of the anti inflammatory effect of allopreg on the brain and cns.. Ssris in low dose raise allopreg
Same with high dose corticosteroids which are anti inflammatory in the cns. This whole thing looks like it has some autoimmune component in it (my ana titer was 1:640 which is high, high enough i went to the rheumatologist but they could not find any distinct antibodies)
Low neurosteroids should lead to anxiety, many of us have total absence of anxiety so i think there is more going on. I think the short lived windows ppl see on low dose ssri reinstatement could be because of the anti inflammatory effect of allopreg on the brain and cns.. Ssris in low dose raise allopreg
Same with high dose corticosteroids which are anti inflammatory in the cns. This whole thing looks like it has some autoimmune component in it (my ana titer was 1:640 which is high, high enough i went to the rheumatologist but they could not find any distinct antibodies)
Last edited by cdraham on Mon Aug 23, 2021 3:28 pm, edited 1 time in total.
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
I am actually doing some research in this area right now and I came up with some good leads. High progesterone, low neurosteroids, 3a HSD seems to be downregulated. Theres some other metabolic alteration going on that leads to this blunted and coma like feeling.
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
Brother, how can I contact you? This is one of the most credible theories.
As Propecia alters levels of neurosteroids and behaves in an anti-androgen manner similarly, antidepressants do the same, albeit through a different pathway. They are both anti-androgens at the end of the day, and explains why the majority of PSSD recovery stories in recent years have a larger focus on altering hormones.
This is why I suggested some to try Ultra Hard, which includes EpiAndrosterone and Androsterone, so seemingly a perfect match for us. Trazohell, may he rest in piece had a glowing recommendation for this product, so if anyone is willing to try it, certainly let me know. We need more people on this!
As Propecia alters levels of neurosteroids and behaves in an anti-androgen manner similarly, antidepressants do the same, albeit through a different pathway. They are both anti-androgens at the end of the day, and explains why the majority of PSSD recovery stories in recent years have a larger focus on altering hormones.
This is why I suggested some to try Ultra Hard, which includes EpiAndrosterone and Androsterone, so seemingly a perfect match for us. Trazohell, may he rest in piece had a glowing recommendation for this product, so if anyone is willing to try it, certainly let me know. We need more people on this!
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
I dont think the drugs directly alter the enzyme (permanently) . What sounds much more plausible is thst that the drugs triggered something that affects this enzyme, i have some good leads and if anything comes out of this research i will let you know
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
Btw. You said you think our allopregnanolone is high, in contrast to pfs guys. I thought this too until i discovered some very interesting things. There are metabolites in the brain that can act on GABA too, just like allopregnanolone. If this metabolite is constantly high you get absence of anxiety too. Low allopregnanolone fits more, because we see people with high progesterone here. But it may vary from sufferer from sufferer. Im convinced the absence of anxiety is not allopregnanolone anymore though
Also i dont think this has directly to do with methylations.. The drugs did not methylate the androgen receptor or something, epigenetic changes are down stream of something bigger. The autoimmune antibodies are a big hint
Also i dont think this has directly to do with methylations.. The drugs did not methylate the androgen receptor or something, epigenetic changes are down stream of something bigger. The autoimmune antibodies are a big hint
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
Certainly agree with some things, disagree with others. You are correct in thinking that Allopregnanlone may indeed not be high, but success with Ultra Hard certainly shows.
As for methylation, there is no doubt that androgens are methylated, but they are not the only thing to be methylated. PSSD is more or less the same as PFS, so clues for them are clues for us. Check out the Baylor study, but I agree - this is more than just simply androgens.
As for methylation, there is no doubt that androgens are methylated, but they are not the only thing to be methylated. PSSD is more or less the same as PFS, so clues for them are clues for us. Check out the Baylor study, but I agree - this is more than just simply androgens.
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
The ultra hard showed the same pattern as with the high progesterone imo, 3a HSD downregulated will also affect Testosterone and DHT of course. When you put DHT on your balls, you get androgen receptors agonized which will make them work again. However the cause of this is something different, not sheer epigenetic changes, there is something upstream causing those issuesYoucanwin wrote: ↑Mon Aug 23, 2021 3:44 pm Certainly agree with some things, disagree with others. You are correct in thinking that Allopregnanlone may indeed not be high, but success with Ultra Hard certainly shows.
As for methylation, there is no doubt that androgens are methylated, but they are not the only thing to be methylated. PSSD is more or less the same as PFS, so clues for them are clues for us. Check out the Baylor study, but I agree - this is more than just simply androgens.
Re: Enzyme question progesterone allopreg 3α-Hydroxysteroid dehydrogenase
Fluoxetine is said to induce 3a-HSD, but what this study says is it instead inhibits reverse oxidation back to 5a-DHP. So it's not clear in what way it happens
RoDH - Retinol Dehydrogenase - enzyme is affected by also Isotretinoin, the drug that causes post accutane syndrome. Some of PSSD patients like me that are having more prominent neurological symptoms show many similarities with PAS patients. I think this is could be why.
- https://www.pasforum.info/forums/theories-of-pas.9/
- https://bpspubs.onlinelibrary.wiley.com ... /bph.12891
Sigma receptors are interesting topic and I think they should be talked about as well. "Neurosteroids" (especially Progesterone) binds to sigma-1. They modulate "intracellular calcium signalling", through IP3r. Also they modulate the "SERT" and "5HT2C" receptors (inhibits dopamine and noradreline) too.
DMT and DXM is agonist at sigma-1, and I think this could be why some got better after trying Ayahuasca (even cured) or DXM. (You should never take DXM regardless)
- https://en.m.wikipedia.org/wiki/Sigma-1_receptor
- viewtopic.php?f=20&t=648&p=5524&hilit=Ayahuasca#p5524
RoDH - Retinol Dehydrogenase - enzyme is affected by also Isotretinoin, the drug that causes post accutane syndrome. Some of PSSD patients like me that are having more prominent neurological symptoms show many similarities with PAS patients. I think this is could be why.
- https://www.pasforum.info/forums/theories-of-pas.9/
- https://bpspubs.onlinelibrary.wiley.com ... /bph.12891
Sigma receptors are interesting topic and I think they should be talked about as well. "Neurosteroids" (especially Progesterone) binds to sigma-1. They modulate "intracellular calcium signalling", through IP3r. Also they modulate the "SERT" and "5HT2C" receptors (inhibits dopamine and noradreline) too.
DMT and DXM is agonist at sigma-1, and I think this could be why some got better after trying Ayahuasca (even cured) or DXM. (You should never take DXM regardless)
- https://en.m.wikipedia.org/wiki/Sigma-1_receptor
- viewtopic.php?f=20&t=648&p=5524&hilit=Ayahuasca#p5524
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