I think I know now what PSSD is

General discussions. Feel free to use this like a support group also.
SilentSufferer
Posts: 8
Joined: Fri Apr 30, 2021 4:52 pm

I think I know now what PSSD is

Unread post by SilentSufferer »

Hi,
I'm a PSSD longtime sufferer from Netherlands after Trazodone.
My Andrologist measured my androgen sensitivity with a special gene test and my fears have come true: I have only 27 CAG repeats, i.e. partial androgen resistance.
He prescribed me TRT but it do a shit. So I believe PSSD is basically the same as PFS, perhaps only other focal points are affected.
In short: we are pretty fucked and I have no more hope now.
Sorry I can't be more positive but you don't know how tired I'm of all this...
Frog
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Re: I think I know now what PSSD is

Unread post by Frog »

Given that there are many cured cases and some members such as TalkingAnt have found relief, I don’t think that we are fucked or hopeless.
fellow1
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Re: I think I know now what PSSD is

Unread post by fellow1 »

Thats interesting. I was doing some research on CAG repeats. Huntingtons' patients have very high CAGs. But questions is does SSRI have much potency to alter CAGs ? Or maybe high CAG repeats is predisposition factor to PSSD.
no_name01010
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Re: I think I know now what PSSD is

Unread post by no_name01010 »

What does It mean?
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TalkingAnt
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Re: I think I know now what PSSD is

Unread post by TalkingAnt »

People are observed with CAG repeat length above 27 not presenting PSSD or sexual dysfunction.

There is no evidence PSSD alters your genome (ie AR CAG repeats), but it may alter your epigenome.

If there is androgen insensitivity, I suspect it involves downregulated AR in the brain (such as in the medial preoptic area). Some PSSD patients, including myself, have had success with TRT (w/HCG). But it may take supraphysiological doses to upregulate brain AR.
Cured | PSSD 2012-2020 | Log thread
Jaxx
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Re: I think I know now what PSSD is

Unread post by Jaxx »

Can you share which doctor did this test and was to what extent is he aware of PSSD (research)?
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