This Webinar is comprehensive on the topic of Post-SSRI Sexual Dysfunction (PSSD), hosted by the International Society for Sexual Medicine (ISSM), with the participation of Professor David Healy, psychiatrist, psychopharmacologist now working in Cananda, and Professor Yacov (Cobi) Reisman, urologist and sexologist in the Netherlands.
If you have the opportunity to share this video with patients, potential patients, specialists and doctors, it would be very helpful.
Perhaps the only important detail not considered here, due to the fact that it is so recent, is the first experimental study on this subject that was published, an Italian study which examined neurosteroid levels in rats during and after the administration of an SSRI, paroxetine, and found persistent changes following its discontinuation. This is very interesting, but it remains to be seen whether these changes are the same as those that can cause persistent sexual (sometimes also sensory, emotional and cognitive) dysfunction in some people who have previously taken serotonergic drugs.
Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis (2021) https://authors.elsevier.com/c/1dTfu15hUdTGgL
Link to the full text valid until 14 September 2021.
I think you are already familiar with David Healy’s intensive work on PSSD. Regular updates and news can be found on the https://Rxisk.org blog.
You can submit a report of persistent drug effects on the Rxisk Report and at the end select that you want to receive update news.
Here is a summary page (something that is missing from wikipedia for PSSD at the moment): https://rxisk.org/post-ssri-sexual-dysfunction-pssd/.
Also Reisman has already written about PSSD in the literature:
- Post-SSRI sexual dysfunction, 2020, https://www.bmj.com/content/368/bmj.m754.long
Are There Any Sex/Gender Differences in Post-Selective Serotonin Reuptake Inhibitors (SSRI) Sexual Dysfunction? 2019, https://www.researchgate.net/publicatio ... ction_PSDD
Sexual Consequences of Post-SSRI Syndrome, 2017, https://pubmed.ncbi.nlm.nih.gov/28642048/
Just a few slides from the webinar: