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PSSD VS PWS

Posted: Wed Jan 13, 2021 11:34 am
by Naczoz
So I wonder ... does PSSD is part of protracted withdrawal syndrome or its strictly separate thing?

Re: PSSD VS PWS

Posted: Wed Jan 13, 2021 1:42 pm
by narigator
The main hypothesis of this study is that PSSD might be a withdrawal syndrome occurring after discontinuation of SSRIs or SNRIs and that withdrawal symptoms might include a wider variety of sexual manifestations: https://pubmed.ncbi.nlm.nih.gov/31834096/

Re: PSSD VS PWS

Posted: Wed Jan 13, 2021 2:48 pm
by Naczoz
So if is one of many symptomsof withdrawal syndrome it means that i will resolve in time?

Re: PSSD VS PWS

Posted: Wed Jan 13, 2021 4:58 pm
by narigator
I think so

Re: PSSD VS PWS

Posted: Thu Jan 14, 2021 7:49 am
by Delfador
pssd IS a form of Post Acute Withdrawal Syndrome.

And no, paws doesn't generally resolve in time. That's half the cases on beyondblue forum.

Re: PSSD VS PWS

Posted: Thu Jan 14, 2021 9:37 am
by Naczoz
So anhedonia and loss of sexual functions are new standard of my 'life'? How come many people vegetate like this for years?

Re: PSSD VS PWS

Posted: Sun Jan 17, 2021 11:35 am
by Delfador
Naczoz wrote: Thu Jan 14, 2021 9:37 am So anhedonia and loss of sexual functions are new standard of my 'life'? How come many people vegetate like this for years?
Because they have better things going in their lives to care about their lack of libido maybe? No offense naczoz ;)

Re: PSSD VS PWS

Posted: Sun Jan 17, 2021 11:36 am
by Naczoz
WTF, its not only about lack of libido - its about being emotionally disconnected!

Re: PSSD VS PWS

Posted: Mon Jan 18, 2021 10:41 am
by finities infinities
Yes, this is like PAWS, Only more complicated and difficult to reverse. In addition to epigenetic issues, I believe that just an unnatural increase in serotonin ( and prolactin) levels in tonic manner would be sufficieent, cause these symptoms. For example after 5htp. Indeed, when susceptibility is present it does not take long for presynaptic 5ht1a to suddenly desensitize, causing a flood of serotonin in hypothalamus and glutamate in PFC ( 5ht1a inhibit glutamate release also!) that will suddenly desensitize AR, OT and MOR and suppress the HPA axis, endocannabinoid activity. This is like post-MDMA symptoms with presynaptic ( and automatically AR) desensitization. DNA methylation is another reason, but I haven't fully figured out the mystery yet. But I know that SSRIs and TCAs reduce SERT expression.