Drugs/supplements that improves pssd permamently.
Drugs/supplements that improves pssd permamently.
So I just wonder.
Many people try various drugs/supplements and they have windows at best and than they return to baseline or crash.
Maybe we can make some list of drugs/supplements that actually improved us permamently.
In my case it was inositol that restored orgasm sensation.
Many people try various drugs/supplements and they have windows at best and than they return to baseline or crash.
Maybe we can make some list of drugs/supplements that actually improved us permamently.
In my case it was inositol that restored orgasm sensation.
Re: Drugs/supplements that improves pssd permamently.
Rebound from acute 5-ht2a inverse agonists like mirtazapine improves a bit emotional blunting and anaesthesia. The effect seems additive and somewhat persistent.
Works only in non-depressed mood, probably via cytokine pathway ( TNF-a is indirectly pro-glutaminergic, affects synaptic plasticity: acute exposure - positively, chronic - negatively ) or by restoring down-stream sensitivity of 5-ht2a receptor function by transitively lowering its baseline activity in cortex layers
Works only in non-depressed mood, probably via cytokine pathway ( TNF-a is indirectly pro-glutaminergic, affects synaptic plasticity: acute exposure - positively, chronic - negatively ) or by restoring down-stream sensitivity of 5-ht2a receptor function by transitively lowering its baseline activity in cortex layers
Re: Drugs/supplements that improves pssd permamently.
so you got permament improvement from mirtazapine? or you just saying this bro-science bullshit?
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Re: Drugs/supplements that improves pssd permamently.
I think that is not from 5ht2a rebound, because mianserin and mirtazapine downregulate this receptor, but probably do you mean alpha 1 adrenergic receptor- which is pro- empathy and pro emotional.
Re: Drugs/supplements that improves pssd permamently.
i dont care, reply to the topic or go somewhere else.
Re: Drugs/supplements that improves pssd permamently.
Bupropion permanently improved my penile sensitivity.
Re: Drugs/supplements that improves pssd permamently.
how long did you took it, what dose and how long its been post quitting? any side effects?
Re: Drugs/supplements that improves pssd permamently.
I used it for over a year at a dose of 150mg. No side effects during use. I tried to increase it to 300mg, but it created agitation and anxiety. The benefit was maintained even without use. However, I felt more fatigued when I left the medication, unable to recover naturally. But this may be due to chronic depression.
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Re: Drugs/supplements that improves pssd permamently.
Last edited by PsychoGenesis on Thu Nov 12, 2020 1:45 pm, edited 1 time in total.
Re: Drugs/supplements that improves pssd permamently.
Go figure yourself. Not gonna waste my time on someone with such attitude.
If this was 5-ht2a downregulation then improvement after 5-ht2a antagonist / inverse agonists would be immediate, positively correlated with a dose and duration of treatment. This happens in your case ? You got better after acute or chronic antipsychotics or antidepressants ? By my experience, I would say quite the opposite, - that chronic blockade of 5-ht2a makes PSSD worse, especially emotional blunting. Only rebound from acute dosing seems to acts different, in a certain specific circumstancesI think that is not from 5ht2a rebound, because mianserin and mirtazapine *downregulate this receptor,*
Not true. This relates to binding site, not actionbc only inverse agonists can do it to this receptor
Inverse agonists are not named as such because "downregulation" of 5-HT2a, but because they lower constant, constitutive activity of 5-ht2a. This is unusual for metabotropic GPCR receptors, 5-Ht2a works in such way only in the cortex.
Last edited by sylv on Thu Nov 12, 2020 1:36 pm, edited 4 times in total.
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