desensitization 5ht1a

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JustOnlyHope
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Re: desensitization 5ht1a

Unread post by JustOnlyHope »

Thomas wrote: Tue Feb 09, 2021 7:53 am I had a good window on hydroxyzine, when I forgot this website, but after a while I fell again in the "overthinking" loop and am now much lower. Don't do the same mistake ;)
What do you mean? Psychological thing worse your PSSD?
Thomas
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Re: desensitization 5ht1a

Unread post by Thomas »

JustOnlyHope wrote: Tue Feb 09, 2021 10:12 am
Thomas wrote: Tue Feb 09, 2021 7:53 am I had a good window on hydroxyzine, when I forgot this website, but after a while I fell again in the "overthinking" loop and am now much lower. Don't do the same mistake ;)
What do you mean? Psychological thing worse your PSSD?
Yes. Obviously, thinking about PSSD increases anxiety thus sexual dysfunction.
I have a baseline with mild PSSD. When I don't feel well (anxiety, lack of sleep, etc.), I am way below my baseline.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine, November 2019-January 2020. Escitalopram, Feb-May 2020.
Symptoms: low libido | sexual numbness | insomnia
JustOnlyHope
Posts: 51
Joined: Fri Dec 25, 2020 10:23 am
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Re: desensitization 5ht1a

Unread post by JustOnlyHope »

Thomas wrote: Tue Feb 09, 2021 10:15 am
JustOnlyHope wrote: Tue Feb 09, 2021 10:12 am
Thomas wrote: Tue Feb 09, 2021 7:53 am I had a good window on hydroxyzine, when I forgot this website, but after a while I fell again in the "overthinking" loop and am now much lower. Don't do the same mistake ;)
What do you mean? Psychological thing worse your PSSD?
Yes. Obviously, thinking about PSSD increases anxiety thus sexual dysfunction.
I have a baseline with mild PSSD. When I don't feel well (anxiety, lack of sleep, etc.), I am way below my baseline.

Get it, hope you will get better...
Calm Amygdala
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Re: desensitization 5ht1a

Unread post by Calm Amygdala »

Meso wrote: Sat Feb 06, 2021 2:46 pm
JustOnlyHope wrote: Sat Feb 06, 2021 2:25 pm My psychiatrist told me it’s good idea to take Vortioxetine but just only 5 mg.
I crashed from Vortioxetine before. I don't think it's a good idea as it would downregulate 5HT1A receptors too much. Are you off of all drugs now?

You might be interested in raising SERT and increasing 5HT1A autoreceptors' sensitivity. Cannabigerol (CBG) is a 5HT1A antagonist. Berberine and Evodiamine upregulate SERT, but Berberine has 5-alpha reductase inhibitory effect. Aside from these, there are research chemicals that work the same but more selectively.

In my opinion, it was the Trazodone inducing your symptoms, not the Bupropion, since SRI reinstatement benefited you a little.
What research chems would you recommend to antagonize 5ht1a and upregulate sert, and do you have a site you recommend?
highman
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Re: desensitization 5ht1a

Unread post by highman »

Hi,

Berberine works on 5HT1a receptors right? After use this my erection is worst It's not full. It's chance to reverse this?
ErgogenicHealth
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Re: desensitization 5ht1a

Unread post by ErgogenicHealth »

highman wrote: Sun Jul 18, 2021 8:43 am Hi,

Berberine works on 5HT1a receptors right? After use this my erection is worst It's not full. It's chance to reverse this?
It will reverse. What about your response to ALCAR?
highman
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Re: desensitization 5ht1a

Unread post by highman »

ErgogenicHealth wrote: Sun Jul 18, 2021 10:40 pm
highman wrote: Sun Jul 18, 2021 8:43 am Hi,

Berberine works on 5HT1a receptors right? After use this my erection is worst It's not full. It's chance to reverse this?
It will reverse. What about your response to ALCAR?
I didn't check it. I feel even worse emotionally. I'm afraid it's not going to get better.
Tree
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Re: desensitization 5ht1a

Unread post by Tree »

highman wrote: Wed Jul 21, 2021 5:19 pm
ErgogenicHealth wrote: Sun Jul 18, 2021 10:40 pm
highman wrote: Sun Jul 18, 2021 8:43 am Hi,

Berberine works on 5HT1a receptors right? After use this my erection is worst It's not full. It's chance to reverse this?
It will reverse. What about your response to ALCAR?
I didn't check it. I feel even worse emotionally. I'm afraid it's not going to get better.
I crashed from a 5ht1a agonist too and never recovered. What are your symptoms? Do you have any worsening cognitive symptoms?
Impermanence
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Re: desensitization 5ht1a

Unread post by Impermanence »

Berberine is also 5a-inhibitor...
But I also think I crashed from Rodhiola Rosea and worsened. I was like 4 months after the beginning of PSSD so hard to say if it was the desease by itself or the Rodhiola...
highman
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Re: desensitization 5ht1a

Unread post by highman »

Tree wrote: Wed Jul 21, 2021 8:46 pm
highman wrote: Wed Jul 21, 2021 5:19 pm
ErgogenicHealth wrote: Sun Jul 18, 2021 10:40 pm

It will reverse. What about your response to ALCAR?
I didn't check it. I feel even worse emotionally. I'm afraid it's not going to get better.
I crashed from a 5ht1a agonist too and never recovered. What are your symptoms? Do you have any worsening cognitive symptoms?
I feel more tired and depressed. Erections are very weak after this.

@Impermanence, Rodhiola increase 5ht1a receptors. May can help for this.
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