Search found 170 matches

by guacamo
Thu Nov 24, 2022 9:19 pm
Forum: Treatments and experimentation
Topic: Everything we knew about PSSD is wrong. Check out why.
Replies: 45
Views: 13295

Re: Everything we knew about PSSD is wrong. Check out why.

You have made some bold posts in the past, with interesting ideas but very limited practical implications and at a key moment, testing a hypothesis, never reported back. So my feedback might sound a bit negative; there are plenty of theories around pssd, without clinical proof/ markers etc about th...
by guacamo
Thu Nov 24, 2022 7:53 am
Forum: Treatments and experimentation
Topic: Everything we knew about PSSD is wrong. Check out why.
Replies: 45
Views: 13295

Re: Everything we knew about PSSD is wrong. Check out why.

I was not on the forum for quite a long time, but I am still passively reading, this thread might be somewhat outdated. I was pretty much inexperienced in the phenomena of PSSD back then. Since then i expanded my knowledge tremendously. It is quite funny that i made pretty good shoots back then whil...
by guacamo
Wed Jun 29, 2022 7:46 pm
Forum: Treatments and experimentation
Topic: SJW Always Cures My PSSD- kramdrol OP
Replies: 545
Views: 190629

Re: SJW Always Cures My PSSD- kramdrol OP

There are several of SJW success stories, these successful stories were mostly with Perika (2% hyperforin) and Laif (3% hyperforin and 0.3% hypericin) brands. Take notice that most of these sjw extracts that are standarized to certain amount of hyperforin or hypericin, will still have the other one,...
by guacamo
Sat Jun 25, 2022 8:26 am
Forum: General
Topic: Curious to hear from folks here whether my hormone results are indicative of PSSD
Replies: 7
Views: 1303

Re: Curious to hear from folks here whether my hormone results are indicative of PSSD

You did not specify really what health problem you are troubled with, but regardless of that i do not think that taking HCG will help you, as i said if you have any health concerns, it is unlikely that they are related to the blood test you mentioned.
by guacamo
Fri Jun 24, 2022 9:08 am
Forum: General
Topic: Curious to hear from folks here whether my hormone results are indicative of PSSD
Replies: 7
Views: 1303

Re: Curious to hear from folks here whether my hormone results are indicative of PSSD

PSSD is 100% not hormonal as indicated by PSSD subpopulation having normal hormones or fluctuation that would otherwise be explained by simple standard deviation that occurs normaly when you have a lot of people tested. Your hormone results are very good regardless of your age and within that range ...
by guacamo
Fri Dec 17, 2021 8:20 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 85
Views: 18881

Re: Final theory of PSSD etiology. Get in here!

I do not think that taking reboxetine is the way to go. There are two ways of how desensitization works. There is heterologous desensitization where ligand no longer exert cellular response in the receptor. After this happens receptor becomes internalized. This is what i think is happening in PSSD. ...
by guacamo
Mon Dec 06, 2021 9:26 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 85
Views: 18881

Re: Final theory of PSSD etiology. Get in here!

In terms of scientific evidence i have no idea. But as anecdotal evidence points out, people who developed PSSD have been often previously hypersexual. We also know from anecdotal reports that excessive masturbation can lead to erectile disfunction, low libido and anhedonia, symptoms very similar to...
by guacamo
Mon Dec 06, 2021 7:18 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 85
Views: 18881

Re: Final theory of PSSD etiology. Get in here!

Take note if you do the trial and take anything that is antagonist of 5-HT7 receptor it might not work. 5-HT7 receptor has the highest selectivity for serotonin out of all 5-HT receptors family. IC50 for 5-HT7 receptor for serotonin is according to studies of about 0.86, for example IC50 for 5HT2A i...
by guacamo
Sat Dec 04, 2021 2:45 pm
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 85
Views: 18881

Re: Final theory of PSSD etiology. Get in here!

I guess sildenafil works, but if you have no libido i think there is nothing that can be done.
by guacamo
Sat Dec 04, 2021 2:08 pm
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 85
Views: 18881

Re: Final theory of PSSD etiology. Get in here!

SJW is not SSRI, it has affinity to a lot of receptors, more than 40. It does not inhibit serotonin transporter like SSRI, why it reuptakes serotonin is a matter of a debate, some articles say its due to increase of intracellular sodium, but it is debatable. It does not feel like SSRI at all. Here y...