Search found 170 matches

by guacamo
Fri Jul 09, 2021 1:11 pm
Forum: General
Topic: What is the "crash"?
Replies: 18
Views: 3464

Re: What is the "crash"?

I know there is potential for crash with every substance, however i would rather become a retard or get brain damage trying to cure PSSD, than live that way till the rest of my days. Hope some of you share this line of thinking.
by guacamo
Fri Jul 09, 2021 1:06 pm
Forum: General
Topic: SSRI worsening ADHD symptoms?
Replies: 3
Views: 445

Re: SSRI worsening ADHD symptoms?

Simply saying ADHD etiology is that in some areas of the brain like prefrontal cortex, which controls things like attention, compulsivity, decision-making, etc. there is reduced dopamine firing. SSRIs are known to lower dopamine firing too, because serotonin receptors are involved in dopamine releas...
by guacamo
Fri Jul 09, 2021 11:30 am
Forum: Treatments and experimentation
Topic: Hopeless and depressed
Replies: 47
Views: 6628

Re: Hopeless and depressed

It is anxiogenic for some and that is part of lack of popularity of reboxetine , but of course some find NET inhibition helpful. There are people that feel great on them.
by guacamo
Fri Jul 09, 2021 10:22 am
Forum: Speculations and hypotheses
Topic: I think i am close to discovering the cure.
Replies: 37
Views: 10429

Re: I think i am close to discovering the cure.

lol, this broscience will do more harm then good for community, many people crashed from substances mentioned in this pathetic topic. better focus on gathering money for research then do this pityfull broscience Ye whole scientific world tries to find cure for neurodegenerative diseases and best th...
by guacamo
Fri Jul 09, 2021 3:06 am
Forum: General
Topic: My introduction and experience with treatment
Replies: 4
Views: 1161

Re: My introduction and experience with treatment

Taking inositol and sjw is counterproductive, because sjw is IP3 antagonist and it might play a part in it being efficious in PSSD. I would rather take lithium with sjw as they both complement each other in that department.
by guacamo
Fri Jul 09, 2021 2:09 am
Forum: Treatments and experimentation
Topic: Hopeless and depressed
Replies: 47
Views: 6628

Re: Hopeless and depressed

In very layman terms bupropion: dopamine - motivation and noradrenaline - anxiety, adding selegiline - very high dopamine: very high motivation alongside other things that happen when you increase dopamine, with no noradrenaline and anxiety. Selegiline dose can be very low like 1mg.
by guacamo
Fri Jul 09, 2021 2:02 am
Forum: Speculations and hypotheses
Topic: I think i am close to discovering the cure.
Replies: 37
Views: 10429

Re: I think i am close to discovering the cure.

You can probably just hop off.
by guacamo
Thu Jul 08, 2021 7:30 am
Forum: Treatments and experimentation
Topic: Hopeless and depressed
Replies: 47
Views: 6628

Re: Hopeless and depressed

I have no recommendations for you, but you can microdose selegiline to reduce anxiety inducing effects of bupropion. It happens because bupropion which has high affinity for dopamine transporter metabolizes in the liver through cytochrome P450 isozyme CYP2B6 to hydroxybupropion which reaches much hi...
by guacamo
Thu Jul 08, 2021 6:57 am
Forum: General
Topic: How to lower estrogen?
Replies: 1
Views: 636

Re: How to lower estrogen?

Losing excess body fat, supplementing natural aromatase inhibitors like zinc, magnesium, selenium, reducing carbohydrates intake, reducing alcohol consumption, exercise. High prolactin may be due to using some medications, especially those that block dopamine receptors like antipsychotics, also traz...
by guacamo
Thu Jul 08, 2021 6:18 am
Forum: General
Topic: Help! antidepressants advice
Replies: 8
Views: 1594

Re: Help! antidepressants advice

I had the same problem and initiate pristiq (desvenlafaxine). Its Very similar to venlafaxine. Help me with depression and in the 50mg dosis my sexuality os better than dont use antidepressant (after I got pssd of course). I tried 100mg Also but the erectyle disfunction worse. I'm still considering...