Search found 110 matches

by lookingforacure
Sat Nov 11, 2023 5:44 pm
Forum: General
Topic: Study: Endorphins in Male Impotence: Evidence for Naltrexone Stimulation of Erectile Activity in Patient Therapy
Replies: 9
Views: 15750

Study: Endorphins in Male Impotence: Evidence for Naltrexone Stimulation of Erectile Activity in Patient Therapy

Abstract In the present study we evaluated whether naltrexone administration could stimulate sexual function in 30 male patients, ages 25 to 50 years, with idiopathic impotence of at least one year's duration and not of organic etiology. The patients received naltrexone (50 mg/day) or placebo, on a ...
by lookingforacure
Sat Nov 11, 2023 5:11 pm
Forum: General
Topic: Chronic Administration of Naltrexone Upregulates Opioid Receptors
Replies: 0
Views: 16171

Chronic Administration of Naltrexone Upregulates Opioid Receptors

Here’s more discussion on the Wikipedia page explaining that prolonged use of naltrexone has been observed to increase opioid receptors. Based on available evidence, naltrexone seems to have minimal untoward effects in the aforementioned areas, at least with long-term therapy, .[45][46][47][48] It h...
by lookingforacure
Sat Nov 11, 2023 8:05 am
Forum: General
Topic: Naltrexone was the only thing that helped me at all
Replies: 71
Views: 45721

Re: Naltrexone was the only thing that helped me at all

Not that I noticed at all.
by lookingforacure
Thu Nov 09, 2023 4:25 pm
Forum: General
Topic: Naltrexone was the only thing that helped me at all
Replies: 71
Views: 45721

Re: Naltrexone was the only thing that helped me at all

Please read the Wikipedia entry on the pharmacology behind Naltrexone’s mechanism of action; here is part of it, maybe it’s relevant. Naltrexone and its active metabolite 6β-naltrexol are competitive antagonists of the opioid receptors.[77][78] Naltrexone is specifically an antagonist preferentially...
by lookingforacure
Thu Nov 09, 2023 4:21 pm
Forum: General
Topic: Naltrexone was the only thing that helped me at all
Replies: 71
Views: 45721

Re: Naltrexone was the only thing that helped me at all

Why do you say conversely? Don’t they both significantly involve opioid receptors (specifically the MOR)?
by lookingforacure
Thu Nov 09, 2023 12:45 pm
Forum: General
Topic: What can I take for social anxiety?
Replies: 1
Views: 10333

Re: What can I take for social anxiety?

Alliant hemp sells extremely cheap cbd oil- they have a bottle of 24,000 mg cbd with a cbd/thc ratio of 100:1. I didn’t know anything about cbd oil until recently, but I tried it and it works really well- just 20-50 mg is perfect for me.
by lookingforacure
Fri Nov 03, 2023 5:21 pm
Forum: General
Topic: Naltrexone was the only thing that helped me at all
Replies: 71
Views: 45721

Re: Naltrexone was the only thing that helped me at all

My pssd was caused by a combination of an ssri and lamictal. I took around 12.5 mg maybe twice a week for a couple of months (it’s in my post history).
by lookingforacure
Fri Nov 03, 2023 5:17 pm
Forum: General
Topic: If you don’t have the courage to try something new, you’re probably going to have PSSD a lot longer
Replies: 6
Views: 12591

Re: If you don’t have the courage to try something new, you’re probably going to have PSSD a lot longer

I appreciate your comment! I’m just frustrated because I feel like I’m shouting into a void, and I’m quite certain some people would be significantly helped by this. Im sorry that you couldn’t take it. I wish you the best in your recovery and in life!
by lookingforacure
Fri Nov 03, 2023 3:14 pm
Forum: General
Topic: If you don’t have the courage to try something new, you’re probably going to have PSSD a lot longer
Replies: 6
Views: 12591

If you don’t have the courage to try something new, you’re probably going to have PSSD a lot longer

I’ve made several posts now detailing just how much Naltrexone has permanently improved my PSSD. I’ve explained how it got worse immediately before taking a week or so to improve, and that the improvements largely stuck. I know there are thousands of you on here that read these posts daily waiting f...
by lookingforacure
Tue Oct 31, 2023 8:57 pm
Forum: General
Topic: Naltrexone was the only thing that helped me at all
Replies: 71
Views: 45721

Naltrexone was the only thing that helped me at all

I feel bad that very few people here seem to have tried naltrexone. It’s the only thing I’ve taken that’s significantly permanently improved my PSSD symptoms. There are some studies that show that chronic naltrexone administration significantly sensitizes certain opioid receptors, and I hypothesize ...