Search found 695 matches

by anacleta
Tue Mar 26, 2024 10:03 am
Forum: PSSD related research
Topic: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
Replies: 4
Views: 783

Re: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2

Thanks, that's interesting! It gives us hope! That said, PIEZO2 might not be involved in the pleasure of sensations : In clinical evaluations and surveys, three men and two women with PIEZO2-deficiency syndrome reported severe hyposensitivity in genital sensation. Despite their marked mechanosensor...
by anacleta
Tue Mar 26, 2024 5:36 am
Forum: PSSD related research
Topic: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
Replies: 4
Views: 783

Re: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2

The Form and Function of PIEZO2 (2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794004/ "Given that PIEZO2 has several physiological roles, even if selective agonists and/or antagonists are identified, systemic drug delivery methods may not safely treat a single function in isolation. Inco...
by anacleta
Tue Mar 26, 2024 4:39 am
Forum: PSSD related research
Topic: Vincristine increases sensation/neuropathic pain by potentiating PIEZO2
Replies: 4
Views: 783

Vincristine increases sensation/neuropathic pain by potentiating PIEZO2

from a previous article: "PIEZO2 function is needed for triggering a touch-evoked erection reflex and successful mating in both male and female mice. Humans with complete loss of PIEZO2 function have genital hyposensitivity and experience no direct pleasure from gentle touch or vibration" ...
by anacleta
Mon Mar 11, 2024 10:29 am
Forum: PSSD related research
Topic: Neuropathy and genital fibrosis, hypothesis and speculation on PSSD
Replies: 0
Views: 695

Neuropathy and genital fibrosis, hypothesis and speculation on PSSD

Patients with PSSD show on average high rates of genital fibrosis, or scar tissue, which can cause or worsen symptoms of erectile dysfunction and genital numbness. Clinical studies on patients with PSSD about it: - Waldinger MD, van Coevorden RS, Schweitzer DH, Georgiadis J. Penile anesthesia in Pos...
by anacleta
Thu Feb 29, 2024 5:01 am
Forum: PSSD related research
Topic: Results of a new study on genital/peripheral nerve treatment of patients with PSSD, PFS and PAS
Replies: 2
Views: 1310

Results of a new study on genital/peripheral nerve treatment of patients with PSSD, PFS and PAS

Dr Kenneth M Peters, urologist at Beaumont Hospital, Royal Oak, Michigan, on 23 February 2024 anticipates the results of a forthcoming study on Twitter https://twitter.com/KennethMPeters1/status/1761131131376681245 NM094 | POST-RETINOID, POST-FINASTERIDE AND POST-SSRI SYNDROMES: PATIENT EVALUATION A...
by anacleta
Thu Nov 23, 2023 12:50 pm
Forum: General
Topic: POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE
Replies: 0
Views: 20794

POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE

Frontiers in Neuroendocrinology Available online 21 November 2023, 101114 POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Roberto Cosimo Melcangi Dipartimento di Scienze Farmacologic...
by anacleta
Fri Nov 10, 2023 2:40 am
Forum: General
Topic: Frequency of self-reported persistent post-treatment genital hypesthesia among past antidepressant users: a cross-se....
Replies: 0
Views: 18378

Frequency of self-reported persistent post-treatment genital hypesthesia among past antidepressant users: a cross-se....

Frequency of self-reported persistent post-treatment genital hypesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US AUTHORS Yassie Pirani Jorge Andres Delgado-Ron Pedro Marino Dr. Amit Gupta Emily Gray Sarah Watt Kinnon R MacKin...
by anacleta
Wed Sep 27, 2023 5:09 am
Forum: PSSD related research
Topic: Sexual touch - (PIEZO2)
Replies: 3
Views: 6734

Re: Sexual touch - (PIEZO2)

I contacted an author of the latest study on piezo2 and sexual function; he has not yet responded, however, I passed the study to Melcangi and he replied that PIEZO2 is already under their attention and they are getting data for both finasteride and SSRI :!: These are long analyses and it takes time...