Search found 217 matches

by Coraggio
Wed Jul 24, 2019 6:15 am
Forum: General
Topic: Coraggio's free Speaking Thread
Replies: 1
Views: 1169

Coraggio's free Speaking Thread

This thread for speaking each other about Melcangi's study and other news that you can find in the Coraggio's Corner- Private.
by Coraggio
Wed Jul 24, 2019 6:09 am
Forum: General
Topic: Coraggio's Corner - Private
Replies: 1
Views: 1251

Re: Coraggio's Corner - Private

1) Melcangi's STUDY INTRO: Maybe someone remember that I have fund a research with Professor Melcangi, a neuroendocrinopharmacologist professore of Milan University. He studies neurosteroids, that are steroid hormones other than sexual o glucocorticoid steroid that are made by glands and, in partic...
by Coraggio
Wed Jul 24, 2019 5:42 am
Forum: General
Topic: Coraggio's Corner - Private
Replies: 1
Views: 1251

Coraggio's Corner - Private

Hi everybody, it has passed something since last time I have written on the forum. I' ve read once a month if there were any news but, in this period, I have restarted most of my life activities and I have no longer many time to spend here. I create this section and I ask you if you don' t leave any...
by Coraggio
Thu Sep 27, 2018 8:21 am
Forum: New Member Intros
Topic: Dangerwood intro / Near natural recovery
Replies: 8
Views: 5786

Re: Dangerwood intro / Near natural recovery

Dangerwood Intro / Near Natural Recovery Hi everyone. Been lurking this site for a couple years now but for good reason. Believe me I have wanted to post for a while now about my story / near recovery but I wanted to wait several months to make sure 100% that what I’m telling you isn’t just a phase...
by Coraggio
Thu Sep 27, 2018 8:07 am
Forum: PSSD related research
Topic: GABA A3/4/5, inflammation and mitochondria
Replies: 25
Views: 10694

Re: GABA A3/4/5, inflammation and mitochondria

Glad to see talking and reaserching about gaba. Gaba plays a big role in our pathogenesis. We need to upregulate naturally
allopregnenolone and alpha4 gaba receptor subunit. Chronic SSRI downregulate both ( while acutely upregulate allpregnanolone biosynthesis).
by Coraggio
Sat Aug 25, 2018 2:06 pm
Forum: Speculations and hypotheses
Topic: 5-ht theory and steroidogenesis [Coraggio's corner]
Replies: 83
Views: 32074

Re: 5-ht theory and steroidogenesis

I think I have found the final lick to understand the situation 1. First article: https://www.ncbi.nlm.nih.gov/m/pubmed/15936112/ "Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1. Morita K, et al. B...
by Coraggio
Fri Jul 13, 2018 8:14 pm
Forum: Treatments and experimentation
Topic: Low Dose SSRI (Reinstatement)
Replies: 515
Views: 200743

Re: low dose ssri

Very interesting. One step to lower cortisol is avoid stimulant like caffeine. It raises testosterone and cortisol acutely but more the last one, so try to lower caffeine as you can Second, I ve found beta-carotene and retinoids(vit A that is its metabolite) can: 1 accumulates in dopaminergic brain ...
by Coraggio
Tue Jul 03, 2018 3:02 am
Forum: PSSD related research
Topic: Buspar (Buspirone)
Replies: 64
Views: 21999

Re: Could Buspar cause Pssd?

I think you are right however my dr now wants me to go on Paxil. I have tried ssri’s in the past and did not tolerate them well. My ability to orgasm did come back after using them though (lexapro about 2 weeks and cymbalta for a week). Still it worries me knowing what could potentially happen. She...
by Coraggio
Sat Jun 30, 2018 7:29 am
Forum: General
Topic: Pssd and SIADH
Replies: 5
Views: 3398

Re: Pssd and SIADH

Very good info man. I highly suggest everyone to test electrolites, albuminemia and BUN/creatinine ratio in their blood test with the hormone levels.

Tell me, how about your protein intake? Does it is very insufficient or not?
by Coraggio
Fri Jun 29, 2018 5:15 pm
Forum: General
Topic: Pssd and SIADH
Replies: 5
Views: 3398

Pssd and SIADH

Guys.. I have no time in this month but would looking better about ADH levels. It is well recognised by the literature SSRI can do an ADH imbalance. ADH means Anti Diuretic Peptide and is secreted by neurohypophysis (like oxytocin). ADH regulates sodium balance.sodium is essential for neurons depola...