Search found 217 matches

by Coraggio
Wed Feb 14, 2018 2:57 am
Forum: General
Topic: Valproate acid
Replies: 27
Views: 6662

Re: Valproate acid

I was reacently reading about Valproaic acid on gene expression. It is potent active demethylation agent trough HDAC inhibiton https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125788/ https://www.ncbi.nlm.nih.gov/pubmed/12748177 http://www.pnas.org/content/105/36/13614.full It can also induce neuroplas...
by Coraggio
Sun Feb 11, 2018 4:30 pm
Forum: Treatments and experimentation
Topic: Low Dose SSRI (Reinstatement)
Replies: 515
Views: 204434

Re: low dose ssri

We are a kind of iatrogen autistic like people, and we have depleted both serotonin and gaba neurotransmission.
by Coraggio
Mon Jan 22, 2018 4:00 am
Forum: General
Topic: I overcame PSSD with pure dedicaton!!!
Replies: 10
Views: 4225

Re: I overcame PSSD with pure dedicaton!!!

Great Man!! Your words give us a lot of hope. Thank you so much. I hope you will be here every now and to support guys they want follow your steps (like me).
by Coraggio
Sat Jan 20, 2018 5:04 pm
Forum: General
Topic: Symptoms become a lot better when I have the flu
Replies: 24
Views: 6261

Re: Symptoms become a lot better when I have the flu

I think you are right. Maybe also because TNF-alpha acutely activates SERT function.
by Coraggio
Sat Jan 20, 2018 2:03 pm
Forum: Speculations and hypotheses
Topic: 5-ht theory and steroidogenesis [Coraggio's corner]
Replies: 83
Views: 32276

Re: 5-ht theory and steroidogenesis

I think I have found the final lick to understand the situation 1. First article: https://www.ncbi.nlm.nih.gov/m/pubmed/15936112/ "Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1. Morita K, et al. B...
by Coraggio
Fri Jan 19, 2018 10:09 am
Forum: PSSD related research
Topic: Read this if you want to end PSSD for good
Replies: 12
Views: 6091

Re: Read this if you want to end PSSD for good

Done. Thanks for the organization.

OT: I am going to update soon about Melcangi.
by Coraggio
Sat Jan 13, 2018 1:35 pm
Forum: General
Topic: Brain Food Nutrition
Replies: 4
Views: 2659

Re: Brain Food Nutrition

Intermittent fasting
by Coraggio
Wed Dec 27, 2017 1:57 pm
Forum: New Member Intros
Topic: Dryed Intro
Replies: 16
Views: 5263

Re: I'm new 9 days on paxil

Listen what Ghost has told you! Do it! Go to your doctor, take the prescription and run to buy the liquid and then taper off very gently. I want to understand better:why do you have decided to cold turkey only after 9 days? How much there were your sexual symptoms? And now after cold turkey your sym...
by Coraggio
Sun Dec 24, 2017 12:01 pm
Forum: Treatments and experimentation
Topic: L-Cysteine and L-Histidine
Replies: 72
Views: 21262

Re: L-Cysteine and L-Histidine

And also DOLT once mentioned that there are no endorphine like feeling after exercises, but i found that the only thing that can help with it is 10 km fast walk on hill(at least for me) I have started training in July almost every day. i do running, cycling, swimming and playnig sports. Now I have ...
by Coraggio
Thu Dec 21, 2017 2:49 am
Forum: Treatments and experimentation
Topic: L-Cysteine and L-Histidine
Replies: 72
Views: 21262

Re: L-Cysteine and L-Histidine

Interesting, I m going to look it into..