Search found 135 matches

by guacamo
Fri Dec 17, 2021 8:20 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

I do not think that taking reboxetine is the way to go. There are two ways of how desensitization works. There is heterologous desensitization where ligand no longer exert cellular response in the receptor. After this happens receptor becomes internalized. This is what i think is happening in PSSD. ...
by guacamo
Mon Dec 06, 2021 9:26 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

In terms of scientific evidence i have no idea. But as anecdotal evidence points out, people who developed PSSD have been often previously hypersexual. We also know from anecdotal reports that excessive masturbation can lead to erectile disfunction, low libido and anhedonia, symptoms very similar to...
by guacamo
Mon Dec 06, 2021 7:18 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

Take note if you do the trial and take anything that is antagonist of 5-HT7 receptor it might not work. 5-HT7 receptor has the highest selectivity for serotonin out of all 5-HT receptors family. IC50 for 5-HT7 receptor for serotonin is according to studies of about 0.86, for example IC50 for 5HT2A i...
by guacamo
Sat Dec 04, 2021 2:45 pm
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

I guess sildenafil works, but if you have no libido i think there is nothing that can be done.
by guacamo
Sat Dec 04, 2021 2:08 pm
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

SJW is not SSRI, it has affinity to a lot of receptors, more than 40. It does not inhibit serotonin transporter like SSRI, why it reuptakes serotonin is a matter of a debate, some articles say its due to increase of intracellular sodium, but it is debatable. It does not feel like SSRI at all. Here y...
by guacamo
Sat Dec 04, 2021 2:02 pm
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

They work sinergistically so they complement each other, you take inositol to create PIP2, and PIP2 is created via PI5K enzyme, whcich needs phosphatidic acid, which to be created via phospholipase D, it needs phosphatidylcholine. Just remember to observe your body reaction and start slowly. If you ...
by guacamo
Sat Dec 04, 2021 12:24 pm
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

Im doing Inositol (18 grams)and Phosphatidyl choline (6grams) starting today. Are the dosages and forms alright? I didnt get the jump from phosphatidylcholine to lechitin in what you were saying, im guessing its also a type of choline? Also want to throw out there that I took Ropinirole (1/2 a pill...
by guacamo
Fri Dec 03, 2021 10:11 am
Forum: General
Topic: Crash from masturbation
Replies: 10
Views: 1191

Re: Crash from masturbation

Dude u have no idea what u talk about, masturbating 7 times a day can be detrimental to health. There are people who have ED simply from masturbation and there are thousands of anegdotal reports about it. Masturbation to porn is not healthy at all.
by guacamo
Fri Dec 03, 2021 9:21 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

Your trial include inositol and lecithin, is that correct?
by guacamo
Thu Dec 02, 2021 2:34 pm
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 84
Views: 9832

Re: Final theory of PSSD etiology. Get in here!

Very interesting stuff. Any reason to mention inositol more so than sjw in the follow up discussion? My observation is that many people have had some type of response to sjw, but fewer people report back on inositol. I do not know, if someone reacts better to sjw then i would advice to try that fir...