Search found 324 matches

by kpavel
Thu Mar 28, 2024 4:49 pm
Forum: PSSD related research
Topic: WHERE DID OUR LOVE GO? Serotonergic drugs weaken insula and amplify ventromedial prefrontal cortex
Replies: 0
Views: 56

WHERE DID OUR LOVE GO? Serotonergic drugs weaken insula and amplify ventromedial prefrontal cortex

In this topic I will put relevant research to prove the statement in the title. Feelings of lust and love lost because of SSRI 'antidepressants' mode of action. Then other aspects of PSSD in the context and my thoughts on technical details and what could possibly be done. Your thoughts, critics and...
by kpavel
Tue Jun 14, 2022 1:43 pm
Forum: General
Topic: Opipramol
Replies: 3
Views: 679

Re: Opipramol

Welcome to the forum, one guy @Steven (RIP) claimed that opipramol destroyed his libido. Search is above. May help sleep though. Also wiki says it's not only h1 histamine receptor antagonist but a strong ligand for sigma1. Because hormones like dhea, pregnenolone and progesterone are ligands for sig...
by kpavel
Sat Jun 04, 2022 12:07 pm
Forum: PSSD related research
Topic: Progesterone
Replies: 236
Views: 61808

Re: Progesterone

I found Trilostane, but it's not prescribed to humans.
by kpavel
Fri Apr 22, 2022 2:05 am
Forum: Treatments and experimentation
Topic: PSSD proven to be autoimmun related!?
Replies: 28
Views: 5659

Re: PSSD proven to be autoimmun related!?

I've looked at Prevotella and noted that it could be related to periodontitis which in turn is associated many times with ED and could be autoimmune. https://pubmed.ncbi.nlm.nih.gov/?term=periodontitis+erectile https://pubmed.ncbi.nlm.nih.gov/27664383/ Should I then not suffer from severe periodont...
by kpavel
Thu Apr 21, 2022 3:02 pm
Forum: Treatments and experimentation
Topic: PSSD proven to be autoimmun related!?
Replies: 28
Views: 5659

Re: PSSD proven to be autoimmun related!?

I've looked at Prevotella and noted that it could be related to periodontitis which in turn is associated many times with ED and could be autoimmune.

https://pubmed.ncbi.nlm.nih.gov/?term=p ... s+erectile
https://pubmed.ncbi.nlm.nih.gov/27664383/
by kpavel
Fri Apr 15, 2022 10:16 am
Forum: Speculations and hypotheses
Topic: Pssd could be an ghrelin dysfunction induced by serotonin 2c antagonism that caused antibodies on that same receptor
Replies: 20
Views: 15273

Re: Pssd could be an ghrelin dysfunction induced by serotonin 2c antagonism that caused antibodies on that same receptor

Interesting, how you would explain it, since appetite sounds and is a hedonic stuff, but alpha-msh is prosexual and supports @male@ hormones too (oppositely to NPY or AgRP). Perhaps high dose DHA could be a solution, that at least theoretically helps to downregulate 5ht2cr and affect ghrelin. Ghreli...
by kpavel
Sat Jan 08, 2022 7:29 am
Forum: Treatments and experimentation
Topic: Being on Bupropion improves my PSSD
Replies: 16
Views: 3651

Re: Being on Bupropion improves my PSSD

I found a study saying Bakuchiol from Psoralea has similar potency on DAT and NET transporters as bupropion. It's also an ERalpha agonist. And it's used for sexual problems either.
by kpavel
Sat Jan 08, 2022 7:25 am
Forum: General
Topic: Biofilms
Replies: 1
Views: 685

Re: Biofilms

by kpavel
Tue Dec 07, 2021 10:49 am
Forum: PSSD related research
Topic: PSSD can be triggered by mitochondrial instability
Replies: 83
Views: 20975

Re: PSSD can be triggered by mitochondrial instability

Well, there is a gigantic thread on this exact topic with a protocol to reverse mitochondrial damage on Longecity: https://www.longecity.org/forum/topic/94224-manipulating-mitochondrial-dynamics/page-1 The newest protocol is here : https://www.longecity.org/forum/topic/94224-manipulating-mitochondr...
by kpavel
Sun Dec 05, 2021 3:43 am
Forum: General
Topic: I have a budget of 2 000 000 € to heal ... How should I use this money ?
Replies: 10
Views: 1977

Re: I have a budget of 2 000 000 € to heal ... How should I use this money ?

I earn some money from my investments I made before I suffered from anhedonia ( Now money doesn't interest me anymore unfortunately ... ) I said to my neurologist : Big Pharma destroyed my life and don't want to help me. They make a lot of money from my sufferings so I have one option left to heal ...