Search found 448 matches

by cdraham
Tue Jan 03, 2023 2:57 pm
Forum: Treatments and experimentation
Topic: I appear to be immune to exogenous androgens.
Replies: 7
Views: 1344

Re: I appear to be immune to exogenous androgens.

If sex hormone receptors in the brain are silenced, you can boost androgens but there wont be much more activity at the receptor. androgen and estrogen signal in the brain stays low. the only chance we have is demethylation regimens or gene therapy at this point
by cdraham
Fri Nov 25, 2022 5:02 pm
Forum: Treatments and experimentation
Topic: I appear to be immune to exogenous androgens.
Replies: 7
Views: 1344

Re: I appear to be immune to exogenous androgens.

Is this something that has been observed in PSSD affected people? Not only do they have no effect whatsoever on sex drive, but also on other typical effect of steroids such as improved strength, endurance, recovery, etc. I have tried: ---Testosterone gel (up to 200mg/day dosage for a week) No effec...
by cdraham
Fri Jun 17, 2022 4:10 pm
Forum: Treatments and experimentation
Topic: Theories on estrogen and sex hormones (temporary full remission after 15 years)
Replies: 8
Views: 1861

Re: Theories on estrogen and sex hormones (temporary full remission after 15 years)

I think in the rebound you restored some estrogen signalling

my bet is that your estrogen pills did not work, because the receptors itself are silenced or downregulated

when you took AI and discontinued, estrogen receptor mRNA upregulated for some time (rebound)
by cdraham
Tue May 31, 2022 7:23 am
Forum: General
Topic: Symptom Remission Regimen and my thoughts on this condition
Replies: 10
Views: 1774

Re: Symptom Remission Regimen and my thoughts on this condition

Wicksy1995 wrote: Tue May 31, 2022 7:14 am I should be okay as my dose isn’t too high, I just have to watch out for symptoms. I honestly wouldn’t know what else to try as I’ve exhausted basically every option available
You think once you notice symptom its early enough to quit it and be fine without permanent damage?
by cdraham
Tue May 31, 2022 7:10 am
Forum: General
Topic: Symptom Remission Regimen and my thoughts on this condition
Replies: 10
Views: 1774

Re: Symptom Remission Regimen and my thoughts on this condition

Arent you afraid of getting tardive dyskenesia from antipsychotics? Like rexulti

Is there any better or safer 5ht1a pre agonist out there?
by cdraham
Tue Apr 19, 2022 6:19 pm
Forum: Treatments and experimentation
Topic: Did someone trial plain 5ht1a agonism + TRT?
Replies: 1
Views: 816

Did someone trial plain 5ht1a agonism + TRT?

I got my biggest window from 5ht1a agonism, like DXM high dose, although DXM is very dirty so it could have been a different mechanism No reaction to MDMA and psychedelics This makes me think in PSSD there is actually a hypersensitive pre-synaptic 5ht1a autoreceptor, which puts a brake on neuronal 5...
by cdraham
Tue Apr 19, 2022 3:04 pm
Forum: General
Topic: Aphantasia Induced by SSRIS
Replies: 14
Views: 4255

Re: Aphantasia Induced by SSRIS

Its a sign the membrane potential of neurons has changed
by cdraham
Tue Apr 19, 2022 3:02 pm
Forum: General
Topic: Crackling in brain
Replies: 8
Views: 1603

Re: Crackling in brain

I have that too. I think its brain zaps and its a sign of high extracellular serotonin in the brain.