Search found 276 matches

by Tree
Wed Feb 21, 2024 6:06 am
Forum: Treatments and experimentation
Topic: Hypertonic Sodium Salts/Sodium Bicarb as a treatment for genital numbness
Replies: 4
Views: 1216

Re: Hypertonic Sodium Salts/Sodium Bicarb as a treatment for genital numbness

I started drinking carbonated water and I noticed an increase sensation in my genitals but after a few days it seems to have worn off followed by increased cognitive symptoms. There seems to be some support for your findings "Sertraline may inhibit 5-HTT by inhibiting Na+ channels, increasing t...
by Tree
Mon Feb 12, 2024 1:59 am
Forum: PSSD related research
Topic: An Excellent Explaination of How SSRI's Inhibit Sert
Replies: 74
Views: 78074

Re: An Excellent Explaination of How SSRI's Inhibit Sert

desoxo-narchinol A extracted from Nardostachys jatamansi DC upregulates sert and reverses the sert inhibition of SSRIs. "Among which, kanshone C of aristolane-type sesquiterpenoid inhibited SERT most strongly, while desoxo-nachinol A of nardosinane-type sesquiterpenoid instead enhanced SERT pot...
by Tree
Fri Feb 09, 2024 4:52 am
Forum: Treatments and experimentation
Topic: Severe PSSD Remission/Management with Ketogenic Diet and Low-Dose Lithium
Replies: 19
Views: 3525

Re: Severe PSSD Recovery with Ketogenic Diet and Low-Dose Lithium

Hello all, it’s been a while since I’ve given an update on my situation and I figured I would check back in. In the past few years I’ve been through some very low lows after a crash from memantine. After my crash, I believed that there was truly no hope left for me and that I was better off dead. A...
by Tree
Mon Jan 29, 2024 4:25 am
Forum: Treatments and experimentation
Topic: Severe PSSD Remission/Management with Ketogenic Diet and Low-Dose Lithium
Replies: 19
Views: 3525

Re: Severe PSSD Recovery with Ketogenic Diet and Low-Dose Lithium

Hello all, it’s been a while since I’ve given an update on my situation and I figured I would check back in. In the past few years I’ve been through some very low lows after a crash from memantine. After my crash, I believed that there was truly no hope left for me and that I was better off dead. A...
by Tree
Sat Jan 27, 2024 4:03 am
Forum: PSSD related research
Topic: Final theory of PSSD etiology. Get in here!
Replies: 85
Views: 18663

Re: Final theory of PSSD etiology. Get in here!

I do not think that taking reboxetine is the way to go. There are two ways of how desensitization works. There is heterologous desensitization where ligand no longer exert cellular response in the receptor. After this happens receptor becomes internalized. This is what i think is happening in PSSD....
by Tree
Sat Dec 23, 2023 1:45 am
Forum: Treatments and experimentation
Topic: Spyros 100% cured by Estrogen + TRT
Replies: 51
Views: 62242

Re: Spyros 100% cured by Estrogen + TRT

I'm not cured, but I improved the worst symptoms of PSSD by taking Clomid. I no longer have insomnia or that extreme tiredness that didn't allow me to get out of bed. Instead of total anorgasmia, I can have weak orgasms now. I'm going to flood my body with massive doses of HCG. 1000 IU 3 times a we...
by Tree
Sun Dec 17, 2023 2:23 am
Forum: Treatments and experimentation
Topic: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes
Replies: 6
Views: 11425

Re: Possible treatment for PSSD/Small Fibre Neuropathy. 12 people anecdotes

Strange I have severe pssd with high folate blood levels and I'm super sensitive to b vitamins. I've tried inositol and niacin. Both worsen my extreme insomnia and tinnitus. Research also shows SSRIs methylate the serotonin transporter. Overmethylation symptoms are similar to PSSD symptoms too.
by Tree
Thu Nov 30, 2023 11:06 pm
Forum: General
Topic: I can probably help you improve your symptoms
Replies: 22
Views: 7400

Re: I can probably help you improve your symptoms

heymartinn wrote: Thu Nov 30, 2023 9:19 am
Tree wrote: Thu Nov 30, 2023 12:46 am Naltrexone is a 5-HT1A agonist
Is it though? All I can find is antagonism against several 5HT subtypes but no mention of 5HT1A agonism
There seems to be some interaction with 5ht1a receptors so I'd be cautious.

https://pubmed.ncbi.nlm.nih.gov/29859012/
by Tree
Thu Nov 30, 2023 12:46 am
Forum: General
Topic: I can probably help you improve your symptoms
Replies: 22
Views: 7400

Re: I can probably help you improve your symptoms

I can’t remember for sure, but I’m almost positive I have. Of course you can try it without the naltrexone, but if it doesn’t give you significant improvements, you can always try the naltrexone. This is the only thing that worked for me in any permanent way, and it worked very quickly too. You cla...
by Tree
Wed Nov 29, 2023 9:49 pm
Forum: General
Topic: I can probably help you improve your symptoms
Replies: 22
Views: 7400

Re: I can probably help you improve your symptoms

Op have you tried the hoppy beer without Naltrexone? I'm very skeptical that Naltrexone can help pssd from the research I've done. Alcohol on the other hand can possibly reverse some of the structural epigenetic changes caused by SSRIs.