Search found 848 matches

by Meso
Thu Jan 14, 2021 2:18 pm
Forum: General
Topic: 100 PSSD Stories For Rare Disease Day - Update and Guidelines
Replies: 4
Views: 178

Re: 100 PSSD Stories For Rare Disease Day - Update and Guidelines

I've submitted my story to the rare disease day website. It's a very important step. Thanks climb!
by Meso
Thu Jan 14, 2021 2:15 pm
Forum: Speculations and hypotheses
Topic: PSSD and thyroid
Replies: 8
Views: 270

Re: PSSD and thyroid

I have taken many dopamine agonists over the years, but they haven't helped. What is strange is that by increasing the dosages of thyroid hormones, I still cannot raise my temperature and speed up my metabolism! Mine is hashimoto hypothyroidism, my antibodies are skyrocketing and attacking my thyro...
by Meso
Thu Jan 14, 2021 6:20 am
Forum: Speculations and hypotheses
Topic: PSSD and thyroid
Replies: 8
Views: 270

Re: PSSD and thyroid

I tried bovine dried thyroid from New Zealand, but nothing. The Tsh was very high (20!) But it returned in the range with T3 and T4, but I maintain all the symptoms of hypothyroidism, in addition to those of PSSD. Incidentally, there are theories that T3 desensitises the 5HT1A receptor even more, s...
by Meso
Wed Jan 13, 2021 2:44 pm
Forum: Treatments and experimentation
Topic: Worst offenders for PSSD and things to avoid taking
Replies: 29
Views: 1457

Re: Worst offenders for PSSD and things to avoid taking

Hi Meso, thanks for this list are very helpful. What do you think about antifungal cream with Clotrimazole? Is it as dangerous as ketoconazole? Unfortunately sometimes I get fungal infections and this cream is the only thing that gets me through in a few days. Until now I have never experienced any...
by Meso
Wed Jan 13, 2021 1:56 pm
Forum: Treatments and experimentation
Topic: Successful usage of Flibanserin (Addyi) for men?
Replies: 3
Views: 261

Re: Successful usage of Flibanserin (Addyi) for men?

bremelanotide is Vyleesi, a self-injecting drug to increase libido and arousal. Out of several people who tried Flibanserin already, I know 2 people who said that it improved all their sexual symptoms. taarn (one of them) said that it made him react to psychostimulants again. That aside, Bremelanot...
by Meso
Wed Jan 13, 2021 1:42 pm
Forum: Speculations and hypotheses
Topic: PSSD and thyroid
Replies: 8
Views: 270

Re: PSSD and thyroid

I'm trying low dose Levothyroxine albeit for intense post-covid fatigue, not for PSSD. It provides some energy and a libido boost. It also increased penile sensitivity which is not something that I like. I find that it only works when combined with Rasagiline though; it has no effects when it's take...
by Meso
Sat Jan 09, 2021 3:24 pm
Forum: Polls
Topic: Any chronic Cannabidiol (CBD) experiences?
Replies: 8
Views: 536

Re: Any chronic Cannabidiol (CBD) experiences?

I have not combined CBD with CBG... I might return back to CBG in a few months... RIght now I am stuck on what WORKS for me... which is just Ze 117 SJW on its own. What I am desperate to determine is whether LITHIUM would be good for me if SJW is as well? Any crossover between these two compounds? ...
by Meso
Tue Jan 05, 2021 2:44 pm
Forum: PSSD related research
Topic: Good Guy Histamine & Possible Role In PSSD
Replies: 6
Views: 508

Re: Good Guy Histamine & Possible Role In PSSD

Thomas wrote: Tue Jan 05, 2021 11:35 am Interesting.
Do you think this could explain what happened to me?
1) I had my (only and) first "window" a few days after starting atarax (H1 antagonist)
2) A few weeks later is was gone? (in waves)
Sounds plausible. Atarax is fairly selective.
by Meso
Tue Jan 05, 2021 2:42 pm
Forum: Polls
Topic: Any chronic Cannabidiol (CBD) experiences?
Replies: 8
Views: 536

Re: Any chronic Cannabidiol (CBD) experiences?

CBD made me worse. Although it was a massive dose (400mg) in a hospital setting for a clinical trial. CBG on the other hand, makes me worse initially, followed by a rebound window of cure: https://pssdforum.org/viewtopic.php?f=20&t=4081&p=38416&hilit=cbg#p38416 Interesting. CBD, by its ...
by Meso
Mon Jan 04, 2021 4:28 pm
Forum: Polls
Topic: Any chronic Cannabidiol (CBD) experiences?
Replies: 8
Views: 536

Any chronic Cannabidiol (CBD) experiences?

SSRIs use increases endocannabinoid (eCB) release across several parts of the brain. This facilitated eCB neurotransmission ends up downregulating CB1 and CB2 receptors, as seen in chronic stress models and eating disorders. What happens during acute SSRI withdrawal is, in part, a temporary endocann...